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2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

Nature communications, 2021-11, Vol.12 (1), p.6478-6478, Article 6478

2021

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Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation

Chemical science (Cambridge), 2024-05, Vol.15 (20), p.7667-7678

2024

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Nature (London), 2014-04, Vol.508 (7495), p.222-227

2014

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Comprehensive characterization of the Published Kinase Inhibitor Set

Nature biotechnology, 2016-01, Vol.34 (1), p.95-103

2016

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Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

Chemical science (Cambridge), 2023-11, Vol.14 (43), p.12098-12120

2023

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Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase

ChemMedChem, 2020-07, Vol.15 (13), p.1139-1149

2020

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Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease

ChemMedChem, 2022-02, Vol.17 (4), p.e202100582-n/a

2022

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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

Chemical communications (Cambridge, England), 2021-02, Vol.57 (12), p.1430-1433

2021

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Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

eLife, 2016-03, Vol.5

2016

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Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

Cell, 2008-09, Vol.134 (5), p.793-803

2008

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Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics

Frontiers in chemistry, 2019-08, Vol.7, p.592-592

2019

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Human histone demethylase KDM6B can catalyse sequential oxidations

Chemical communications (Cambridge, England), 2018, Vol.54 (57), p.7975-7978

2018

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Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding

Chemical science (Cambridge), 2021-10, Vol.12 (41), p.13686-13703

2021

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Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals

Communications chemistry, 2023-01, Vol.6 (1), p.12-9, Article 12

2023

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Structural and Functional Characterization of the Human Protein Kinase ASK1

Structure (London), 2007-10, Vol.15 (10), p.1215-1226

2007

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Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

Communications chemistry, 2022-12, Vol.5 (1), p.1-11, Article 27

2022

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The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation

FEBS letters, 2023-04, Vol.597 (7), p.933-946

2023

Volltextzugriff (PDF)

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease reversible covalent acylation

Chemical science (Cambridge), 2024-05, Vol.15 (2), p.7667-7678

2024

Volltextzugriff (PDF)

High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells

Methods in molecular biology (Clifton, N.J.), 2019, Vol.2025, p.191

2019

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Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

PLoS biology, 2010-07, Vol.8 (7), p.e1000426-e1000426

2010

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Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

Journal of fluorine chemistry, 2021-07, Vol.247, p.109804-109804, Article 109804

2021

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Alkyne Derivatives of SARS-CoV‑2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

Journal of medicinal chemistry, 2023-02, Vol.66 (4), p.2663-2680

2023

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Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

PLoS biology, 2010-07, Vol.8 (7), p.e1000426

2010

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Penicillin Derivatives Inhibit the SARS-CoV‑2 Main Protease by Reaction with Its Nucleophilic Cysteine

Journal of medicinal chemistry, 2022-06, Vol.65 (11), p.7682-7696

2022

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Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2‑Hydroxyglutarate

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4525-4540

2024

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2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Comprehensive characterization of the Published Kinase Inhibitor Set

Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase

Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics

Human histone demethylase KDM6B can catalyse sequential oxidations

Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding

Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals

Structural and Functional Characterization of the Human Protein Kinase ASK1

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease reversible covalent acylation

High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

Alkyne Derivatives of SARS-CoV‑2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Penicillin Derivatives Inhibit the SARS-CoV‑2 Main Protease by Reaction with Its Nucleophilic Cysteine

Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2‑Hydroxyglutarate

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