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Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

The New England journal of medicine, 2007-04, Vol.356 (15), p.1517-1526

2007

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Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

Diabetes care, 2009-09, Vol.32 (9), p.1663-1668

2009

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

Nature medicine, 2011-11, Vol.17 (11), p.1481-1489

2011

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TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

Diabetologia, 2014-08, Vol.57 (8), p.1645-1654

2014

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Cytokine production by islets in health and diabetes: cellular origin, regulation and function

Trends in endocrinology and metabolism, 2010-05, Vol.21 (5), p.261-267

2010

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IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction

The Journal of immunology (1950), 2011-09, Vol.187 (5), p.2755-2765

2011

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Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

Endocrinology (Philadelphia), 2009-12, Vol.150 (12), p.5218-5229

2009

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Toll‐like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

Immunology and cell biology, 2014-04, Vol.92 (4), p.314-323

2014

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Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.8908-8917

2016

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Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Diabetes (New York, N.Y.), 2007-09, Vol.56 (9), p.2356-2370

2007

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Mechanisms of β-Cell Death in Type 2 Diabetes

Diabetes (New York, N.Y.), 2005-12, Vol.54 (suppl 2), p.S108-S113

2005

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IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

Diabetologia, 2015-03, Vol.58 (3), p.575-585

2015

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Interleukin-6 regulates pancreatic α-cell mass expansion

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (35), p.13163-13168

2008

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Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1

iScience, 2020-01, Vol.23 (1), p.100775-100775, Article 100775

2020

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Resident Macrophages Mediate Islet Amyloid Polypeptide-Induced Islet IL-1β Production and β-Cell Dysfunction

Diabetes (New York, N.Y.), 2014-05, Vol.63 (5), p.1698-1711

2014

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Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

Diabetes (New York, N.Y.), 2003-03, Vol.52 (3), p.741-750

2003

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Macrophages, cytokines and beta-cell death in Type 2 diabetes

Biochemical Society transactions, 2008-06, Vol.36 (Pt 3), p.340-342

2008

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Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats

PloS one, 2014-02, Vol.9 (2), p.e90045-e90045

2014

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Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

PloS one, 2009-09, Vol.4 (9), p.e6963-e6963

2009

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Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity

The Journal of immunology (1950), 2014-01, Vol.192 (2), p.623-629

2014

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Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes

Physiology (Bethesda, Md.), 2009-12, Vol.24 (6), p.325-331

2009

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Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

Diabetes care, 2008-02, Vol.31 (2), p.S161-S164

2008

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Type 1, Type 1.5, and Type 2 Diabetes: NOD the Diabetes We Thought It Was

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (33), p.12217-12218

2006

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Glucose-dependent Insulinotropic Polypeptide Activates the Raf-Mek1/2-ERK1/2 Module via a Cyclic AMP/cAMP-dependent Protein Kinase/Rap1-mediated Pathway

The Journal of biological chemistry, 2002-10, Vol.277 (40), p.37088-37097

2002

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Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?

Diabetologia, 2014-03, Vol.57 (3), p.447-450

2014

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Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

Toll‐like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Mechanisms of β-Cell Death in Type 2 Diabetes

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

Interleukin-6 regulates pancreatic α-cell mass expansion

Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1

Resident Macrophages Mediate Islet Amyloid Polypeptide-Induced Islet IL-1β Production and β-Cell Dysfunction

Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

Macrophages, cytokines and beta-cell death in Type 2 diabetes

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity

Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes

Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

Type 1, Type 1.5, and Type 2 Diabetes: NOD the Diabetes We Thought It Was

Glucose-dependent Insulinotropic Polypeptide Activates the Raf-Mek1/2-ERK1/2 Module via a Cyclic AMP/cAMP-dependent Protein Kinase/Rap1-mediated Pathway

Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?

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