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Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins

Current protein & peptide science, 2014-01, Vol.15 (5), p.504-517

2014

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Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1273-1278

2013

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Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.737-751

2008

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Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer

PloS one, 2014-08, Vol.9 (8), p.e105688-e105688

2014

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Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design

Structure (London), 2008-02, Vol.16 (2), p.228-238

2008

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N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

Molecular cancer therapeutics, 2008-09, Vol.7 (9), p.2713-2724

2008

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Activation and Catalysis of the Di-Heme Cytochrome c Peroxidase from Paracoccus pantotrophus

Structure (London), 2006, Vol.14 (1), p.107-117

2006

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Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Journal of the American Chemical Society, 2006-05, Vol.128 (18), p.6012-6013

2006

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Oligomeric States of the Detergent-solubilized Human Serum Paraoxonase (PON1)

The Journal of biological chemistry, 2002-09, Vol.277 (36), p.33386-33397

2002

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Long‐term assessment of haematological recovery following somatic genetic rescue in a MYSM1‐deficient patient: Implications for in vivo gene therapy

British journal of haematology, 2024-09

2024

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Recent developments in cyclin-dependent kinase biochemical and structural studies

Biochimica et biophysica acta, 2010-03, Vol.1804 (3), p.511-519

2010

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ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis

Cell death & disease, 2017-08, Vol.8 (8), p.e3021-e3021

2017

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Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

European journal of medicinal chemistry, 2017-01, Vol.126, p.1118-1128

2017

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Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase

ACS medicinal chemistry letters, 2020-04, Vol.11 (4), p.497-505

2020

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Abstract 3236: Delivering selective and cell-active inhibitors of V804M mutant RET kinase through structure-guided drug discovery

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3236-3236

2017

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The COP9 Signalosome: Activity and Regulation

Biophysical journal, 2014-01, Vol.106 (2), p.463a-463a

2014

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Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase

ACS medicinal chemistry letters, 2020-04, Vol.11 (4), p.497-505

2020

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An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

ACS chemical biology, 2014-06, Vol.9 (6), p.1251-1256

2014

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Structure and mechanism in the bacterial dihaem cytochrome c peroxidases

Journal of inorganic biochemistry, 2006-04, Vol.100 (4), p.551-567

2006

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Meriolins, a new class of cell death -Inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (17), p.8325-8334

2007

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8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

Journal of medicinal chemistry, 2014-01, Vol.57 (1), p.56

2014

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The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Essays in biochemistry, 2017-11, Vol.61 (5), p.495-503

2017

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8‑Substituted O 6‑Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode

Journal of medicinal chemistry, 2014-01, Vol.57 (1), p.56-70

2014

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Redox-Linked Structural Changes Associated with the Formation of a Catalytically Competent Form of the Diheme Cytochrome c Peroxidase from Pseudomonas aeruginosa

Biochemistry (Easton), 2008-02, Vol.47 (7), p.1947-1956

2008

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Crystal Structure and Solution NMR Dynamics of a D (Type II) Peroxiredoxin Glutaredoxin and Thioredoxin Dependent: A New Insight into the Peroxiredoxin Oligomerism

Biochemistry (Easton), 2005-02, Vol.44 (6), p.1755-1767

2005

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Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins

Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer

Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

Activation and Catalysis of the Di-Heme Cytochrome c Peroxidase from Paracoccus pantotrophus

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Oligomeric States of the Detergent-solubilized Human Serum Paraoxonase (PON1)

Long‐term assessment of haematological recovery following somatic genetic rescue in a MYSM1‐deficient patient: Implications for in vivo gene therapy

Recent developments in cyclin-dependent kinase biochemical and structural studies

ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase

Abstract 3236: Delivering selective and cell-active inhibitors of V804M mutant RET kinase through structure-guided drug discovery

The COP9 Signalosome: Activity and Regulation

Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

Structure and mechanism in the bacterial dihaem cytochrome c peroxidases

Meriolins, a new class of cell death -Inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

8‑Substituted O 6‑Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode

Redox-Linked Structural Changes Associated with the Formation of a Catalytically Competent Form of the Diheme Cytochrome c Peroxidase from Pseudomonas aeruginosa

Crystal Structure and Solution NMR Dynamics of a D (Type II) Peroxiredoxin Glutaredoxin and Thioredoxin Dependent: A New Insight into the Peroxiredoxin Oligomerism

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