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Spinocerebellar Ataxia Type 3 Pathophysiology-Implications for Translational Research and Clinical Studies

International journal of molecular sciences, 2024-04, Vol.25 (7), p.3984

2024

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Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma

Neoplasia (New York, N.Y.), 2023-10, Vol.44, p.100929-100929, Article 100929

2023

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Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3

PloS one, 2018-08, Vol.13 (8), p.e0201794

2018

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ATXN3 controls DNA replication and transcription by regulating chromatin structure

Nucleic acids research, 2023-06, Vol.51 (11), p.5396

2023

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Rapamycin alleviates toxicity of different aggregate-prone proteins

Human molecular genetics, 2006-02, Vol.15 (3), p.433-442

2006

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Nonsteroidal Anti-Inflammatory Drugs Repress β-Secretase Gene Promoter Activity by the Activation of PPARγ

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (2), p.443-448

2006

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Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen

Scientific reports, 2021-10, Vol.11 (1), p.19857-10, Article 19857

2021

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Reciprocal Regulation between Bifunctional miR-9/9∗ and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation

Stem cell reports, 2016-08, Vol.7 (2), p.207-219

2016

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Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination

Biochemical and biophysical research communications, 2007-10, Vol.362 (3), p.734-739

2007

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Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

Neurobiology of disease, 2008-12, Vol.32 (3), p.521-527

2008

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Inhibition of Intercellular Cytosolic Traffic via Gap Junctions Reinforces Lomustine-Induced Toxicity in Glioblastoma Independent of MGMT Promoter Methylation Status

Pharmaceuticals (Basel, Switzerland), 2021-02, Vol.14 (3), p.195

2021

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Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide

Cancers, 2019-06, Vol.11 (6), p.858

2019

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The Role of MicroRNAs in Spinocerebellar Ataxia Type 3

Journal of molecular biology, 2019-04, Vol.431 (9), p.1729-1742

2019

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Mutant valosin-containing protein causes a novel type of frontotemporal dementia

Annals of neurology, 2005-03, Vol.57 (3), p.457-461

2005

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An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

The EMBO journal, 2006-04, Vol.25 (7), p.1547-1558

2006

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The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)-Implications for Parkinson's Disease and Rett Syndrome

Molecular neurobiology, 2024-03

2024

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Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

Nature (London), 2011-12, Vol.480 (7378), p.543-546

2011

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FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Human molecular genetics, 2011-08, Vol.20 (15), p.2928-2941

2011

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Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma

Neuro-oncology (Charlottesville, Va.), 2021-11, Vol.23 (11), p.1885-1897

2021

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Nuclear Aggregation of Polyglutamine-expanded Ataxin-3

The Journal of biological chemistry, 2010-02, Vol.285 (9), p.6532-6537

2010

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Inflammatory Genes Are Upregulated in Expanded Ataxin-3-Expressing Cell Lines and Spinocerebellar Ataxia Type 3 Brains

The Journal of neuroscience, 2001-08, Vol.21 (15), p.5389-5396

2001

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CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3

Human molecular genetics, 2009-09, Vol.18 (17), p.3334-3343

2009

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Gene Expression Profiling in Ataxin-3 Expressing Cell Lines Reveals Distinct Effects of Normal and Mutant Ataxin-3

Journal of neuropathology and experimental neurology, 2003-10, Vol.62 (10), p.1006-1018

2003

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Nuclear Aggregation of Polyglutamine-expanded Ataxin-3: FRAGMENTS ESCAPE THE CYTOPLASMIC QUALITY CONTROL

The Journal of biological chemistry, 2010-02, Vol.285 (9), p.6532-6537

2010

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Ataxin-3 Represses Transcription via Chromatin Binding, Interaction with Histone Deacetylase 3, and Histone Deacetylation

The Journal of neuroscience, 2006-11, Vol.26 (44), p.11474-11486

2006

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Spinocerebellar Ataxia Type 3 Pathophysiology-Implications for Translational Research and Clinical Studies

Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma

Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3

ATXN3 controls DNA replication and transcription by regulating chromatin structure

Rapamycin alleviates toxicity of different aggregate-prone proteins

Nonsteroidal Anti-Inflammatory Drugs Repress β-Secretase Gene Promoter Activity by the Activation of PPARγ

Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen

Reciprocal Regulation between Bifunctional miR-9/9∗ and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation

Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

Inhibition of Intercellular Cytosolic Traffic via Gap Junctions Reinforces Lomustine-Induced Toxicity in Glioblastoma Independent of MGMT Promoter Methylation Status

Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide

The Role of MicroRNAs in Spinocerebellar Ataxia Type 3

Mutant valosin-containing protein causes a novel type of frontotemporal dementia

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)-Implications for Parkinson's Disease and Rett Syndrome

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma

Nuclear Aggregation of Polyglutamine-expanded Ataxin-3

Inflammatory Genes Are Upregulated in Expanded Ataxin-3-Expressing Cell Lines and Spinocerebellar Ataxia Type 3 Brains

CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3

Gene Expression Profiling in Ataxin-3 Expressing Cell Lines Reveals Distinct Effects of Normal and Mutant Ataxin-3

Nuclear Aggregation of Polyglutamine-expanded Ataxin-3: FRAGMENTS ESCAPE THE CYTOPLASMIC QUALITY CONTROL

Ataxin-3 Represses Transcription via Chromatin Binding, Interaction with Histone Deacetylase 3, and Histone Deacetylation

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