UB Paderborn / Katalog / Suche / in CDI

Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2794-2809

2016

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)

Psychopharmacology, 2005-04, Vol.179 (1), p.271-283

2005

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Screening G Protein-Coupled Receptors: Measurement of Intracellular Calcium Using the Fluorometric Imaging Plate Reader

High Throughput Screening, 2009-01, Vol.565, p.145-158

2009

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Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators

The Journal of pharmacology and experimental therapeutics, 2006-09, Vol.318 (3), p.1108

2006

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Development and implementation of a high-throughput AlphaLISA assay for identifying inhibitors of EZH2 methyltransferase

Assay and drug development technologies, 2013-04, Vol.11 (3), p.152

2013

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Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.5019-5034

2008

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Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling

Molecular and Cellular Biology, 2001-01, Vol.21 (1), p.26-38

2001

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Efficient and Highly Scalable Mechanistic Characterization of Ion Channel Function in Drug Discovery

Biophysical journal, 2020-02, Vol.118 (3), p.579a-579a

2020

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The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase

The Journal of biological chemistry, 2012-10, Vol.287 (44), p.37447-37457

2012

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Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.369

2004

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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

The Journal of pharmacology and experimental therapeutics, 2017-01, Vol.360 (1), p.117

2017

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Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10003-10015

2013

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Development of a homogeneous AlphaLISA ubiquitination assay using ubiquitin binding matrices as universal components for the detection of ubiquitinated proteins

Biochimica et biophysica acta, 2012-11, Vol.1823 (11), p.2038-2045

2012

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6523-6540

2012

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Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8440-8450

2011

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Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings

Experimental hematology, 2013-05, Vol.41 (5), p.491-500

2013

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Ral‐GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation

The EMBO journal, 1996-02, Vol.15 (4), p.810-816

1996

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Rapid Development of Piperidine Carboxamides as Potent and Selective Anaplastic Lymphoma Kinase Inhibitors

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1698-1705

2012

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Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes

The Journal of biological chemistry, 1997-12, Vol.272 (49), p.31182-31189

1997

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Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes

The Journal of biological chemistry, 1997-12, Vol.272 (49), p.31172-31181

1997

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High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

Journal of biomolecular screening, 2012-01, Vol.17 (1), p.27-38

2012

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Potency and Selectivity Assessment of Small Molecules Against Janus Kinase (JAK) 2: Widely Used AG490 Inhibitor Is Neither Potent Nor Selective for JAK2

Blood, 2011-11, Vol.118 (21), p.4780-4780

2011

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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (2), p.323-328

2017

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Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2

The Journal of biological chemistry, 1998-05, Vol.273 (19), p.11548-11555

1998

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Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A

Biochemical and biophysical research communications, 2005-08, Vol.334 (2), p.729-732

2005

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)

Screening G Protein-Coupled Receptors: Measurement of Intracellular Calcium Using the Fluorometric Imaging Plate Reader

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators

Development and implementation of a high-throughput AlphaLISA assay for identifying inhibitors of EZH2 methyltransferase

Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists

Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling

Efficient and Highly Scalable Mechanistic Characterization of Ion Channel Function in Drug Discovery

The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase

Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Development of a homogeneous AlphaLISA ubiquitination assay using ubiquitin binding matrices as universal components for the detection of ubiquitinated proteins

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors

Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings

Ral‐GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation

Rapid Development of Piperidine Carboxamides as Potent and Selective Anaplastic Lymphoma Kinase Inhibitors

Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes

Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes

High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

Potency and Selectivity Assessment of Small Molecules Against Janus Kinase (JAK) 2: Widely Used AG490 Inhibitor Is Neither Potent Nor Selective for JAK2

Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A

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