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A Cell-Targeted Photodynamic Nanomedicine Strategy for Head and Neck Cancers

Molecular pharmaceutics, 2013-05, Vol.10 (5), p.1988-1997

2013

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In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization

The Journal of pharmacology and experimental therapeutics, 2010-12, Vol.335 (3), p.715

2010

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Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

Cancer chemotherapy and pharmacology, 2009-03, Vol.63 (4), p.615-625

2009

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Phase I Pharmacokinetic-Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin (17AAG, NSC 330507), a Novel Inhibitor of Heat Shock Protein 90, in Patients with Refractory Advanced Cancers

Clinical cancer research, 2005-05, Vol.11 (9), p.3385-3391

2005

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Plasma, Tumor, and Tissue Disposition of STEALTH Liposomal CKD-602 (S-CKD602) and Nonliposomal CKD-602 in Mice Bearing A375 Human Melanoma Xenografts

Clinical cancer research, 2007-12, Vol.13 (23), p.7217-7223

2007

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Modulation of Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-Tetrahydrouridine

Clinical cancer research, 2008-06, Vol.14 (11), p.3529-3535

2008

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Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

Cancer chemotherapy and pharmacology, 2005-01, Vol.55 (1), p.21-32

2005

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Phase I and Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients with Refractory Advanced Cancers

Clinical cancer research, 2007-03, Vol.13 (6), p.1769-1774

2007

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Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice

Clinical cancer research, 2006-12, Vol.12 (24), p.7483-7491

2006

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Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine

Clinical cancer research, 2005-05, Vol.11 (10), p.3862-3868

2005

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Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino )-17-demethoxygeldanamycin (17-DMAG), in rats and dogs : potential clinical relevance

Cancer chemotherapy and pharmacology, 2005-12, Vol.56 (6), p.637-647

2005

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Targeting p53-dependent stem cell loss for intestinal chemoprotection

Science translational medicine, 2018-02, Vol.10 (427)

2018

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Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1

Cancer chemotherapy and pharmacology, 2001-04, Vol.47 (4), p.291-302

2001

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Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors

Cancer chemotherapy and pharmacology, 2016-07, Vol.78 (1), p.73-81

2016

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LC–MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma

Journal of pharmaceutical and biomedical analysis, 2016-09, Vol.129, p.359-366

2016

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A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine, administered with tetrahydrouridine

Cancer chemotherapy and pharmacology, 2015-03, Vol.75 (3), p.537-546

2015

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Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer

Molecular cancer therapeutics, 2012-07, Vol.11 (7), p.1389-1399

2012

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Liquid chromatography–tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma

Journal of pharmaceutical and biomedical analysis, 2018-02, Vol.150, p.169-175

2018

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Pharmacology and Antitumor Activity of a Quinolinedione Cdc25 Phosphatase Inhibitor DA3003-1 (NSC 663284)

Anticancer research, 2007-09, Vol.27 (5A), p.3067-3073

2007

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Estimation of body surface area in the musk shrew (Suncus murinus): a small animal for testing chemotherapy-induced emesis

Laboratory animals (London), 2017-10, Vol.51 (5), p.534-537

2017

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Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors

Clinical cancer research, 2007-04, Vol.13 (7), p.2121-2127

2007

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A Mass Balance and Disposition Study of the DNA Methyltransferase Inhibitor Zebularine (NSC 309132) and Three of Its Metabolites in Mice

Clinical cancer research, 2006-10, Vol.12 (19), p.5826-5833

2006

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Oral and intravenous pharmacokinetics of 5-fluoro-2′-deoxycytidine and THU in cynomolgus monkeys and humans

Cancer chemotherapy and pharmacology, 2015-10, Vol.76 (4), p.803-811

2015

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LC–MS/MS assay for the quantitation of the ribonucleotide reductase inhibitor triapine in human plasma

Journal of pharmaceutical and biomedical analysis, 2017-11, Vol.146, p.154-160

2017

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Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database

SLAS discovery, 2019-03, Vol.24 (3), p.242-263

2019

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A Cell-Targeted Photodynamic Nanomedicine Strategy for Head and Neck Cancers

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

Phase I Pharmacokinetic-Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin (17AAG, NSC 330507), a Novel Inhibitor of Heat Shock Protein 90, in Patients with Refractory Advanced Cancers

Plasma, Tumor, and Tissue Disposition of STEALTH Liposomal CKD-602 (S-CKD602) and Nonliposomal CKD-602 in Mice Bearing A375 Human Melanoma Xenografts

Modulation of Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-Tetrahydrouridine

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

Phase I and Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients with Refractory Advanced Cancers

Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice

Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine

Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino )-17-demethoxygeldanamycin (17-DMAG), in rats and dogs : potential clinical relevance

Targeting p53-dependent stem cell loss for intestinal chemoprotection

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1

Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors

LC–MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma

A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine, administered with tetrahydrouridine

Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer

Liquid chromatography–tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma

Pharmacology and Antitumor Activity of a Quinolinedione Cdc25 Phosphatase Inhibitor DA3003-1 (NSC 663284)

Estimation of body surface area in the musk shrew (Suncus murinus): a small animal for testing chemotherapy-induced emesis

Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors

A Mass Balance and Disposition Study of the DNA Methyltransferase Inhibitor Zebularine (NSC 309132) and Three of Its Metabolites in Mice

Oral and intravenous pharmacokinetics of 5-fluoro-2′-deoxycytidine and THU in cynomolgus monkeys and humans

LC–MS/MS assay for the quantitation of the ribonucleotide reductase inhibitor triapine in human plasma

Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database

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