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Animal models of sepsis : Why does preclinical efficacy fail to translate to the clinical setting?

Critical care medicine, 2009, Vol.37 (1), p.S30-S37

2009

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The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching

Antioxidants & redox signaling, 2013-11, Vol.19 (14), p.1690-1710

2013

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Key bioactive reaction products of the NO/H₂S interaction are S/N-hybrid species, polysulfides, and nitroxyl

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (34), p.E4651-E4660

2015

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Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

Hypertension (Dallas, Tex. 1979), 2015-04, Vol.65 (4), p.834-840

2015

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Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

American journal of physiology. Regulatory, integrative and comparative physiology, 2019-05, Vol.316 (5), p.R584-R593

2019

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The Pharmacology and Therapeutic Utility of Sodium Hydroselenide

International journal of molecular sciences, 2021-03, Vol.22 (6), p.3258

2021

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Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

PLoS medicine, 2017-07, Vol.14 (7), p.e1002310

2017

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Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis

PLoS medicine, 2012-11, Vol.9 (11), p.e1001338-e1001338

2012

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Inflammation biomarkers and delirium in critically ill patients

Critical care (London, England), 2014-05, Vol.18 (3), p.R106-R106, Article R106

2014

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Taming hemoglobin chemistry—a new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation

Experimental and Molecular Medicine, 2024, 56(0), , pp.2260-2270

2024

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Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

Intensive care medicine experimental, 2019-12, Vol.7 (1), p.71-13, Article 71

2019

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Monitoring Tissue Perfusion, Oxygenation, and Metabolism in Critically Ill Patients

Chest, 2013-06, Vol.143 (6), p.1799-1808

2013

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Development and translation of thiometallate sulfide donors using a porcine model of coronary occlusion and reperfusion

Redox biology, 2024-07, Vol.73, p.103167, Article 103167

2024

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Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure

JACC. Basic to translational science, 2020-08, Vol.5 (8), p.799-810

2020

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On the origin of nitrosylated hemoglobin in COVID-19: Endothelial NO capture or redox conversion of nitrite?

Redox biology, 2022-08, Vol.54, p.102362, Article 102362

2022

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Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

Critical care medicine, 2009-01, Vol.37 (1 Suppl), p.S30-S37

2009

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Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis

Journal of cerebral blood flow and metabolism, 2016-11, Vol.36 (11), p.1955-1964

2016

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Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Clinical science (1979), 2013-03, Vol.124 (6), p.391-401

2013

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Cardioprotection, attenuated systemic inflammation, and survival benefit of β1-adrenoceptor blockade in severe sepsis in rats

Critical care medicine, 2010-02, Vol.38 (2), p.388-394

2010

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Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Sensing and Bio-Sensing Research, 2020-12, Vol.30, p.100375, Article 100375

2020

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An integrated approach to assessing nitroso-redox balance in systemic inflammation

Free radical biology & medicine, 2011-09, Vol.51 (6), p.1137-1145

2011

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Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Intensive care medicine experimental, 2020-04, Vol.8 (1), p.13-13, Article 13

2020

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The metabolic phenotype of rodent sepsis: cause for concern?

Intensive care medicine experimental, 2013-10, Vol.1 (1), p.25-25, Article 6

2013

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Optimising organ perfusion in the high-risk surgical and critical care patient: a narrative review

British journal of anaesthesia : BJA, 2019-08, Vol.123 (2), p.170-176

2019

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Loss of NF1 in Drosophila Larvae Causes Tactile Hypersensitivity and Impaired Synaptic Transmission at the Neuromuscular Junction

The Journal of neuroscience, 2022-12, Vol.42 (50), p.9450-9472

2022

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Animal models of sepsis : Why does preclinical efficacy fail to translate to the clinical setting?

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching

Key bioactive reaction products of the NO/H₂S interaction are S/N-hybrid species, polysulfides, and nitroxyl

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

The Pharmacology and Therapeutic Utility of Sodium Hydroselenide

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis

Inflammation biomarkers and delirium in critically ill patients

Taming hemoglobin chemistry—a new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation

Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

Monitoring Tissue Perfusion, Oxygenation, and Metabolism in Critically Ill Patients

Development and translation of thiometallate sulfide donors using a porcine model of coronary occlusion and reperfusion

Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure

On the origin of nitrosylated hemoglobin in COVID-19: Endothelial NO capture or redox conversion of nitrite?

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis

Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Cardioprotection, attenuated systemic inflammation, and survival benefit of β1-adrenoceptor blockade in severe sepsis in rats

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

An integrated approach to assessing nitroso-redox balance in systemic inflammation

Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

The metabolic phenotype of rodent sepsis: cause for concern?

Optimising organ perfusion in the high-risk surgical and critical care patient: a narrative review

Loss of NF1 in Drosophila Larvae Causes Tactile Hypersensitivity and Impaired Synaptic Transmission at the Neuromuscular Junction

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