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SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

Neuropsychopharmacology (New York, N.Y.), 2007-10, Vol.32 (10), p.2163-2172

2007

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LABORAS™: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour

Journal of neuroscience methods, 2003-11, Vol.130 (1), p.83-92

2003

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Repeated sensory contact with aggressive mice rapidly leads to an anticipatory increase in core body temperature and physical activity that precedes the onset of aversive responding

The European journal of neuroscience, 2004-08, Vol.20 (4), p.1033-1050

2004

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Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression

Behavioural brain research, 2023-07, Vol.449, p.114473-114473, Article 114473

2023

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3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.737-741

2005

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Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents

Psychopharmacologia, 2002-05, Vol.161 (3), p.314-323

2002

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5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

Psychopharmacologia, 2002-11, Vol.164 (2), p.214-220

2002

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Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS

Neuropharmacology, 2000, Vol.39 (1), p.123-132

2000

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A novel behavioural registration system LABORAS™ and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat

Brain research, 2005-01, Vol.1031 (1), p.118-124

2005

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How good are current approaches to nonclinical evaluation of abuse and dependence?

The Journal of pharmacology and experimental therapeutics, 2011-03, Vol.336 (3), p.588

2011

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Current approaches and issues in non-clinical evaluation of abuse and dependence

Journal of pharmacological and toxicological methods, 2011-03, Vol.63 (2), p.160-167

2011

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The development of an Irwin-like test in the nonhuman primate for CNS safety assessment

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.164-164

2012

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Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement

Psychopharmacologia, 2001-01, Vol.153 (2), p.203-209

2001

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Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats

Psychopharmacologia, 2004-12, Vol.177 (1-2), p.1-14

2004

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Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist

Pharmacology, biochemistry and behavior, 2002-04, Vol.71 (4), p.645-654

2002

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5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

Psychopharmacology, 2002-11, Vol.164 (2), p.214-220

2002

Volltextzugriff (PDF)

SB-649915-B, a novel s-HTIA/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

Neuropsychopharmacology (New York, N.Y.), 2007, Vol.32 (10), p.2163-2172

2007

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Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain

European journal of pharmacology, 2004-06, Vol.493 (1), p.95-98

2004

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3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.737-741

2005

Volltextzugriff (PDF)

3,4-Dihydro-2 H-benzoxazinones are 5-HT 1A receptor antagonists with potent 5-HT reuptake inhibitory activity

Bioorganic & medicinal chemistry letters, 2005, Vol.15 (3), p.737-741

2005

Volltextzugriff (PDF)

Immunohistochemical localisation of the 5-HT 2C receptor protein in the rat CNS

Neuropharmacology, 2000, Vol.39 (1), p.123-132

2000

Volltextzugriff (PDF)

Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist

Pharmacology, biochemistry and behavior, 2002-04, Vol.71 (4), p.645-654

2002

Volltextzugriff (PDF)

Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist: Serotonin: pharmacology, biochemistry and behavior

Pharmacology, biochemistry and behavior, 2002, Vol.71 (4), p.645-654

2002

Volltextzugriff (PDF)

Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT 6 receptor antagonist

Pharmacology, biochemistry and behavior, 2002, Vol.71 (4), p.645-654

2002

Volltextzugriff (PDF)

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement

Psychopharmacology, 2001-01, Vol.153 (2), p.203-209

2001

Volltextzugriff (PDF)

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SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

LABORAS™: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour

Repeated sensory contact with aggressive mice rapidly leads to an anticipatory increase in core body temperature and physical activity that precedes the onset of aversive responding

Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression

3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity

Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents

5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS

A novel behavioural registration system LABORAS™ and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat

How good are current approaches to nonclinical evaluation of abuse and dependence?

Current approaches and issues in non-clinical evaluation of abuse and dependence

The development of an Irwin-like test in the nonhuman primate for CNS safety assessment

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement

Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats

Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

SB-649915-B, a novel s-HTIA/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain

3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity

3,4-Dihydro-2 H-benzoxazinones are 5-HT 1A receptor antagonists with potent 5-HT reuptake inhibitory activity

Immunohistochemical localisation of the 5-HT 2C receptor protein in the rat CNS

Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist

Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist: Serotonin: pharmacology, biochemistry and behavior

Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT 6 receptor antagonist

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement

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