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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Nature communications, 2022-01, Vol.13 (1), p.486-486, Article 486

2022

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice

PloS one, 2012-09, Vol.7 (9), p.e45243-e45243

2012

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Molecular cell, 2016-12, Vol.64 (5), p.875-887

2016

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Targeting the Raf kinases in human cancer: the Raf dimer dilemma

British journal of cancer, 2018-01, Vol.118 (1), p.3-8

2018

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A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

Biochimica et biophysica acta. General subjects, 2020-06, Vol.1864 (6), p.129556-129556, Article 129556

2020

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Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Molecular pharmacology, 2014-03, Vol.85 (3), p.408-419

2014

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Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1743-1754

2021

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Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

Basic research in cardiology, 2015-05, Vol.110 (3), p.31-31, Article 31

2015

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Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Journal of natural products (Washington, D.C.), 2022-06, Vol.85 (6), p.1603-1616

2022

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Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

Molecular pharmacology, 2015-09, Vol.88 (3), p.512-523

2015

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Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction

Journal of natural products (Washington, D.C.), 2020-04, Vol.83 (4), p.1288-1294

2020

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Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3431-3435

2010

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Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor

Investigational new drugs, 2012-08, Vol.30 (4), p.1379-1388

2012

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Development of water soluble derivatives of cis-3, 4′, 5-trimethoxy-3′-aminostilbene for optimization and use in cancer therapy

Investigational new drugs, 2009-02, Vol.27 (1), p.41-52

2009

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Abstract 16201: Combined Treatment of the PI3k/mTOR Inhibitor BEZ235 With Doxorubicin Does Not Increase Cardiotoxicity While Improving Efficacy in Breast Cancer Cells

Circulation (New York, N.Y.), 2014-11, Vol.130 (suppl_2)

2014

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Abstract 16163: Hydrogen Sulfide Reduces Inflammasome Formation in Mice With Ischemic HFrEF

Circulation (New York, N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A16163-A16163

2015

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Development of water soluble derivatives of cis-3, 4 double prime , 5-trimethoxy-3 double prime -aminostilbene for optimization and use in cancer therapy

Investigational new drugs, 2009-02, Vol.27 (1), p.41-52

2009

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ChemInform Abstract: Versatile Synthesis of New Cytotoxic Agents Structurally Related to Hemiasterlins

ChemInform, 2010-11, Vol.41 (45), p.no-no

2010

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Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals

mBio, 2014-08, Vol.5 (5), p.e01476-e01414

2014

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A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Cell, 2015-06, Vol.161 (7), p.1619-1632

2015

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Charge Separation versus Recombination in Dye-Sensitized Nanocrystalline Solar Cells: the Minimization of Kinetic Redundancy

Journal of the American Chemical Society, 2005-03, Vol.127 (10), p.3456-3462

2005

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Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

Cell metabolism, 2016-10, Vol.24 (4), p.555-565

2016

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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2320-2330

2011

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Indolo-naphthyridine-6,13-dione Thiophene Building Block for Conjugated Polymer Electronics: Molecular Origin of Ultrahigh n‑Type Mobility

Chemistry of materials, 2016-11, Vol.28 (22), p.8366-8378

2016

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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Targeting the Raf kinases in human cancer: the Raf dimer dilemma

A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction

Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor

Development of water soluble derivatives of cis-3, 4′, 5-trimethoxy-3′-aminostilbene for optimization and use in cancer therapy

Abstract 16201: Combined Treatment of the PI3k/mTOR Inhibitor BEZ235 With Doxorubicin Does Not Increase Cardiotoxicity While Improving Efficacy in Breast Cancer Cells

Abstract 16163: Hydrogen Sulfide Reduces Inflammasome Formation in Mice With Ischemic HFrEF

Development of water soluble derivatives of cis-3, 4 double prime , 5-trimethoxy-3 double prime -aminostilbene for optimization and use in cancer therapy

ChemInform Abstract: Versatile Synthesis of New Cytotoxic Agents Structurally Related to Hemiasterlins

Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Charge Separation versus Recombination in Dye-Sensitized Nanocrystalline Solar Cells: the Minimization of Kinetic Redundancy

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Indolo-naphthyridine-6,13-dione Thiophene Building Block for Conjugated Polymer Electronics: Molecular Origin of Ultrahigh n‑Type Mobility

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