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Medicinal chemistry design principles for liver targeting through OATP transporters

Current topics in medicinal chemistry, 2013-04, Vol.13 (7), p.857-866

2013

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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-11, Vol.77 (22), p.10050-10057

2012

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High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid

Current topics in medicinal chemistry, 2013-04, Vol.13 (7), p.837-842

2013

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10879-10896

2020

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2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.3114-3125

2018

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Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7110-7119

2013

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Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino-piperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.234-237

2009

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Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.234-237

2009

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MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1

ACS chemical biology, 2015-12, Vol.10 (12), p.2667-2671

2015

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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

ACS medicinal chemistry letters, 2011-05, Vol.2 (5), p.407-412

2011

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Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

Bioorganic & medicinal chemistry, 2013-09, Vol.21 (17), p.5081-5097

2013

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Thyroid receptor agonists for the treatment of androgenetic alopecia

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.306-308

2010

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Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4571-4578

2013

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Total synthesis of the polyether antibiotic ionomycin

Journal of the American Chemical Society, 1990-06, Vol.112 (13), p.5290-5313

1990

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Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

ACS medicinal chemistry letters, 2015-11, Vol.6 (11), p.1128-1133

2015

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Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2652-2655

2009

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Undesired versus designed enzymatic cleavage of linkers for liver targeting

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (4), p.1144-1147

2014

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Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (20), p.6122-6125

2011

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Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

ACS medicinal chemistry letters, 2012-05, Vol.3 (5), p.397-401

2012

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In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity

Biochemical and biophysical research communications, 2010-04, Vol.394 (2), p.366-371

2010

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Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors

Synthesis (Stuttgart), 2012-10, Vol.44 (20), p.3152-3157

2012

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Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5351-5354

2009

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β3-adrenergic agonists: potential therapeutics for obesity

Expert opinion on investigational drugs, 1997-12, Vol.6 (12), p.1811-1825

Dow, Robert L

1997

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Prevention of Proteinuria by a Novel, Subnanomolar ApoL1 Inhibitor: FR-OR105

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.58-58

2023

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Medicinal chemistry design principles for liver targeting through OATP transporters

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino-piperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

Thyroid receptor agonists for the treatment of androgenetic alopecia

Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif

Total synthesis of the polyether antibiotic ionomycin

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Undesired versus designed enzymatic cleavage of linkers for liver targeting

Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity

Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles

β3-adrenergic agonists: potential therapeutics for obesity

Prevention of Proteinuria by a Novel, Subnanomolar ApoL1 Inhibitor: FR-OR105

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