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Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors

Nature communications, 2021-08, Vol.12 (1), p.4775-4775, Article 4775

2021

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Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Journal of the American Chemical Society, 2019-07, Vol.141 (29), p.11522-11530

2019

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Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Journal of the American Chemical Society, 2017-12, Vol.139 (51), p.18522-18535

2017

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New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion

Molecular psychiatry, 2020-09, Vol.25 (9), p.2070-2085

2020

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The role of kinetic context in apparent biased agonism at GPCRs

Nature communications, 2016-02, Vol.7 (1), p.10842-10842, Article 10842

2016

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Optical control of sphingosine-1-phosphate formation and function

Nature chemical biology, 2019-06, Vol.15 (6), p.623

2019

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Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

Molecular psychiatry, 2020-09, Vol.25 (9), p.2086-2100

2020

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What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Pharmacological reviews, 2015-01, Vol.67 (1), p.198-213

2015

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Optical Control of Lysophosphatidic Acid Signaling

Journal of the American Chemical Society, 2020-06, Vol.142 (24), p.10612-10616

2020

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Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens

Neuron (Cambridge, Mass.), 2018-05, Vol.98 (3), p.575-587.e4

2018

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A new mechanism of allostery in a G protein-coupled receptor dimer

Nature chemical biology, 2014-09, Vol.10 (9), p.745

2014

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Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

PloS one, 2016-02, Vol.11 (2), p.e0148684-e0148684

2016

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Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist‐Induced Arrestin Recruitment to Modified and Unmodified G Protein‐Coupled Receptors

Current Protocols in Pharmacology, 2015-09, Vol.70 (1), p.2.14.1-2.14.14

2015

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Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

Journal of the American Chemical Society, 2021-06, Vol.143 (24), p.8951-8956

2021

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Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches

Journal of the American Chemical Society, 2023-08, Vol.145 (34), p.18778-18788

2023

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Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Journal of medicinal chemistry, 2012-08, Vol.55 (15), p.6689-6699

2012

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Photopharmacology for vision restoration

Current opinion in pharmacology, 2022-08, Vol.65, p.102259-102259, Article 102259

2022

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A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors

Molecular pharmacology, 2013-12, Vol.84 (6), p.854-864

2013

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Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D 3 Receptor

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.580-593

2017

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Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.580-593

2017

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Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D2 Receptor Creates an Internalization-defective Receptor

The Journal of biological chemistry, 2014-11, Vol.289 (48), p.33663-33675

2014

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High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6195-6213

2015

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Novel Analogues of (R)‑5-(Methylamino)-5,6-dihydro‑4H‑imidazo[4,5,1-ij]quinolin-2(1H)‑one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.2973-2988

2016

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In‐Cell Arrestin‐Receptor Interaction Assays

Current protocols, 2023-10, Vol.3 (10), p.e890-n/a

2023

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Structural Basis for the Allosteric Pharmacology of SB269652 in Dopamine D2 Receptor

Biophysical journal, 2015-01, Vol.108 (2), p.416a-416a

2015

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Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion

The role of kinetic context in apparent biased agonism at GPCRs

Optical control of sphingosine-1-phosphate formation and function

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Optical Control of Lysophosphatidic Acid Signaling

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens

A new mechanism of allostery in a G protein-coupled receptor dimer

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist‐Induced Arrestin Recruitment to Modified and Unmodified G Protein‐Coupled Receptors

Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Photopharmacology for vision restoration

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D 3 Receptor

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D2 Receptor Creates an Internalization-defective Receptor

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

Novel Analogues of (R)‑5-(Methylamino)-5,6-dihydro‑4H‑imidazo[4,5,1-ij]quinolin-2(1H)‑one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

In‐Cell Arrestin‐Receptor Interaction Assays

Structural Basis for the Allosteric Pharmacology of SB269652 in Dopamine D2 Receptor

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