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Biological Role and Therapeutic Potential of IDH Mutations in Cancer

Cancer cell, 2018-08, Vol.34 (2), p.186-195

2018

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Isocitrate dehydrogenase mutations in gliomas

Neuro-oncology (Charlottesville, Va.), 2016-01, Vol.18 (1), p.16-26

2016

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The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors

The New England journal of medicine, 2021-03, Vol.384 (12), p.1168-1170

2021

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Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA

Acta neuropathologica, 2019-02, Vol.137 (2), p.297-306

2019

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Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (13), p.6308-6312

2019

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Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX -Mutant Cancers to WEE1 Inhibition

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (3), p.510-523

2020

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PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon

Cancer discovery, 2022-06, Vol.12 (6), p.1435-1448

2022

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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

Nature communications, 2018-05, Vol.9 (1), p.2087-11, Article 2087

2018

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The integrated genomic and epigenomic landscape of brainstem glioma

Nature communications, 2020-06, Vol.11 (1), p.3077-3077, Article 3077

2020

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Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

Oncotarget, 2014-03, Vol.5 (6), p.1515-1525

2014

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Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles

The Journal of pathology, 2016-05, Vol.239 (1), p.72-83

2016

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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

Cancer research (Chicago, Ill.), 2017-11, Vol.77 (22), p.6097-6108

2017

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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

The Journal of clinical investigation, 2019-01, Vol.129 (1), p.223-229

2019

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CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP

Molecular cancer research, 2019-10, Vol.17 (10), p.2042-2050

2019

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The Role of Ablative Radiotherapy in Older Adults With Limited Metastatic Disease

Seminars in radiation oncology, 2022-04, Vol.32 (2), p.135-141

2022

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Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

European journal of cancer (1990), 2015-05, Vol.51 (8), p.969-976

2015

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SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma

Modern pathology, 2021-10, Vol.34 (10), p.1810-1819

2021

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Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer

The Journal of clinical investigation, 2021-11, Vol.131 (21), p.1-12

2021

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Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells

Neuro-oncology (Charlottesville, Va.), 2023-09, Vol.25 (9), p.1563-1575

2023

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Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib

Molecular cancer research, 2020-07, Vol.18 (7), p.968-980

2020

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Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas

Neuro-oncology (Charlottesville, Va.), 2019-03, Vol.21 (4), p.440-450

2019

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TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist

Acta neuropathologica communications, 2021-11, Vol.9 (1), p.178-178, Article 178

2021

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(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers

Cancer discovery, 2023-06, Vol.13 (6), p.1478-1497

2023

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Missense Mutations in TCF8 Cause Late-Onset Fuchs Corneal Dystrophy and Interact with FCD4 on Chromosome 9p

American journal of human genetics, 2010, Vol.86 (1), p.45-53

2010

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Biological Role and Therapeutic Potential of IDH Mutations in Cancer

Isocitrate dehydrogenase mutations in gliomas

The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors

Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA

Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX -Mutant Cancers to WEE1 Inhibition

PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

The integrated genomic and epigenomic landscape of brainstem glioma

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles

Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP

The Role of Ablative Radiotherapy in Older Adults With Limited Metastatic Disease

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma

Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer

Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells

Hypoxia-Directed Treatment of Human Papillomavirus-Related Oropharyngeal Carcinoma

Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib

Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas

TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist

(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers

Missense Mutations in TCF8 Cause Late-Onset Fuchs Corneal Dystrophy and Interact with FCD4 on Chromosome 9p

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