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Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity

Clinical pharmacology and therapeutics, 2017-10, Vol.102 (4), p.662-670

2017

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Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5‐Fluorouracil Sensitivity in an East African Population

Clinical pharmacology and therapeutics, 2017-03, Vol.101 (3), p.382-390

2017

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Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy

Clinical cancer research, 2015-05, Vol.21 (9), p.2038-2044

2015

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Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

Clinical cancer research, 2000-04, Vol.6 (4), p.1322-1327

2000

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Methylation of the DPYD Promoter: An Alternative Mechanism for Dihydropyrimidine Dehydrogenase Deficiency in Cancer Patients

Clinical cancer research, 2005-12, Vol.11 (24), p.8699-8705

2005

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Quantitation of Dihydropyrimidine Dehydrogenase Expression by Real-Time Reverse Transcription Polymerase Chain Reaction

Analytical biochemistry, 2000-02, Vol.278 (2), p.175-184

2000

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Profound Dihydropyrimidine Dehydrogenase Deficiency Resulting from a Novel Compound Heterozygote Genotype

Clinical cancer research, 2002-03, Vol.8 (3), p.768-774

2002

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Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil

Clinical cancer research, 1999-08, Vol.5 (8), p.2006-2011

1999

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Housekeeping Gene Variability in Normal and Carcinomatous Colorectal and Liver Tissues: Applications in Pharmacogenomic Gene Expression Studies

Analytical biochemistry, 2002-04, Vol.303 (2), p.209-214

2002

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Phase I Study of Capecitabine With Concomitant Radiotherapy for Patients With Locally Advanced Pancreatic Cancer: Expression Analysis of Genes Related to Outcome

Journal of clinical oncology, 2005-12, Vol.23 (34), p.8679-8687

2005

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Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics

Pharmacogenomics, 2002-07, Vol.3 (4), p.485-492

2002

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Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver : population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

Cancer research (Chicago, Ill.), 1993-11, Vol.53 (22), p.5433-5438

1993

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Antitumor Efficacy of Capecitabine and Celecoxib in Irradiated and Lead-Shielded, Contralateral Human BxPC-3 Pancreatic Cancer Xenografts: Clinical Implications of Abscopal Effects

Clinical cancer research, 2005-12, Vol.11 (24), p.8773-8781

2005

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Randomized placebo-controlled multicenter evaluation of diethyldithiocarbamate for chemoprotection against cisplatin-induced toxicities

Journal of clinical oncology, 1995-02, Vol.13 (2), p.490-496

1995

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Sorivudine and 5‐fluorouracil; a clinically significant drug‐drug interaction due to inhibition of dihydropyrimidine dehydrogenase

British journal of clinical pharmacology, 1998-07, Vol.46 (1), p.1-4

Diasio, Robert B.

1998

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Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance

Clinical cancer research, 1999-10, Vol.5 (10), p.2672

1999

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Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics

Pharmacogenomics, 2005-12, Vol.6 (8), p.835-847

2005

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The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology

Oncology (Williston Park, N.Y.), 1998-10, Vol.12 (10 Suppl 7), p.23

Diasio, R B

1998

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Role of matrix metalloproteinases in colorectal carcinogenesis

Annals of surgery, 2001-06, Vol.233 (6), p.786-792

2001

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Multiple Gene Expression Analyses in Paraffin-Embedded Tissues by TaqMan Low-Density Array: Application to Hedgehog and Wnt Pathway Analysis in Ovarian Endometrioid Adenocarcinoma

The Journal of molecular diagnostics : JMD, 2006-02, Vol.8 (1), p.76-83

2006

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Adjuvant Chemotherapy for Adenocarcinoma of the Lung — Is the Standard of Care Ready for Change?

The New England journal of medicine, 2004-04, Vol.350 (17), p.1777-1779

Diasio, Robert B

2004

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Clinical implications of dihydropyrimidine dehydrogenase inhibition

Oncology (Williston Park, N.Y.), 1999-07, Vol.13 (7 Suppl 3), p.17

Diasio, R B

1999

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Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase

The Journal of biological chemistry, 1994-07, Vol.269 (30), p.19375-19379

1994

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Clinical pharmacology of 5-fluorouracil

Clinical pharmacokinetics, 1989-04, Vol.16 (4), p.215-237

1989

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Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy

Clinical cancer research, 1998-02, Vol.4 (2), p.325-329

1998

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Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity

Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5‐Fluorouracil Sensitivity in an East African Population

Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy

Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

Methylation of the DPYD Promoter: An Alternative Mechanism for Dihydropyrimidine Dehydrogenase Deficiency in Cancer Patients

Quantitation of Dihydropyrimidine Dehydrogenase Expression by Real-Time Reverse Transcription Polymerase Chain Reaction

Profound Dihydropyrimidine Dehydrogenase Deficiency Resulting from a Novel Compound Heterozygote Genotype

Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil

Housekeeping Gene Variability in Normal and Carcinomatous Colorectal and Liver Tissues: Applications in Pharmacogenomic Gene Expression Studies

Phase I Study of Capecitabine With Concomitant Radiotherapy for Patients With Locally Advanced Pancreatic Cancer: Expression Analysis of Genes Related to Outcome

Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver : population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

Antitumor Efficacy of Capecitabine and Celecoxib in Irradiated and Lead-Shielded, Contralateral Human BxPC-3 Pancreatic Cancer Xenografts: Clinical Implications of Abscopal Effects

Randomized placebo-controlled multicenter evaluation of diethyldithiocarbamate for chemoprotection against cisplatin-induced toxicities

Sorivudine and 5‐fluorouracil; a clinically significant drug‐drug interaction due to inhibition of dihydropyrimidine dehydrogenase

Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance

Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics

The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology

Role of matrix metalloproteinases in colorectal carcinogenesis

Multiple Gene Expression Analyses in Paraffin-Embedded Tissues by TaqMan Low-Density Array: Application to Hedgehog and Wnt Pathway Analysis in Ovarian Endometrioid Adenocarcinoma

Adjuvant Chemotherapy for Adenocarcinoma of the Lung — Is the Standard of Care Ready for Change?

Clinical implications of dihydropyrimidine dehydrogenase inhibition

Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase

Clinical pharmacology of 5-fluorouracil

Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy

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