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Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

Current opinion in virology, 2021-08, Vol.49, p.36-40

2021

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Nucleosides for the treatment of respiratory RNA virus infections

Antiviral chemistry & chemotherapy, 2018-01, Vol.26, p.2040206618764483-2040206618764483

2018

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The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase

PloS one, 2013-07, Vol.8 (7), p.e68347

2013

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Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex

Molecules (Basel, Switzerland), 2022-05, Vol.27 (9), p.2918

2022

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Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

PLoS pathogens, 2018-02, Vol.14 (2), p.e1006889-e1006889

2018

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New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B

Antiviral research, 2011-05, Vol.90 (2), p.93-101

2011

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Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Journal of Virology, 2006-12, Vol.80 (24), p.12283-12292

2006

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Advances in antiviral nucleoside analogues and their prodrugs

Antiviral chemistry & chemotherapy, 2018-01, Vol.26, p.2040206618781410-2040206618781410

2018

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Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

Antiviral research, 2020-10, Vol.182, p.104924-104924, Article 104924

2020

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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1862-1878

2015

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Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7504-7516

2015

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

PloS one, 2020-12, Vol.15 (12), p.e0240338

2020

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Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases

PLoS pathogens, 2021-12, Vol.17 (12), p.e1010151-e1010151

2021

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Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naïve and pre-treated HIV infected patients

Journal of medical virology, 2007-03, Vol.79 (3), p.207-211

2007

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Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Antiviral research, 2017-07, Vol.143, p.151-161

2017

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Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase

Antimicrobial Agents and Chemotherapy, 2007-08, Vol.51 (8), p.2920-2928

2007

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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004995-e1004995

2015

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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

International journal of molecular sciences, 2023-11, Vol.24 (22), p.16274

2023

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

British journal of pharmacology, 2014-07, Vol.171 (14), p.3364-3375

2014

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New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase

Antiviral research, 2016-10, Vol.134, p.63-76

2016

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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

PloS one, 2016-05, Vol.11 (5), p.e0154097-e0154097

2016

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Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.830-837

2012

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Antimicrobial Strategies: Inhibition of Viral Polymerases by 3′-Hydroxyl Nucleosides

Drugs (New York, N.Y.), 2009-01, Vol.69 (2), p.151-166

Deval, Jerome

2009

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Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

Antiviral research, 2018-07, Vol.155, p.76-88

2018

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Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

Nucleosides for the treatment of respiratory RNA virus infections

The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase

Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Advances in antiviral nucleoside analogues and their prodrugs

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases

Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naïve and pre-treated HIV infected patients

Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir

Antimicrobial Strategies: Inhibition of Viral Polymerases by 3′-Hydroxyl Nucleosides

Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

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