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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

Molecular cancer therapeutics, 2014-04, Vol.13 (4), p.890-901

2014

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Nature medicine, 2009-07, Vol.15 (7), p.781-787

2009

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Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

Blood, 2007-11, Vol.110 (9), p.3281-3290

2007

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Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

Cancer research (Chicago, Ill.), 2007-07, Vol.67 (13), p.6383-6391

2007

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Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3028-3038

2009

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Validation of the Proteasome as a Therapeutic Target in Plasmodium Using an Epoxyketone Inhibitor with Parasite-Specific Toxicity

Chemistry & biology, 2012-12, Vol.19 (12), p.1535-1545

2012

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The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

Neuron (Cambridge, Mass.), 1991-11, Vol.7 (5), p.743-753

1991

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Cell cycle regulatory E3 ubiquitin ligases as anticancer targets

Drug resistance updates, 2002-12, Vol.5 (6), p.249-258

2002

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A Novel Splice Variant of the Cell Death-promoting Protein BAX

The Journal of biological chemistry, 1998-05, Vol.273 (19), p.11930-11936

1998

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Abstract 1416: CB-839, a novel potent and selective glutaminase inhibitor, has broad antiproliferative activity in cell lines derived from both solid tumors and hematological malignancies

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1416-1416

2014

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ralGDS family members interact with the effector loop of ras p21

Molecular and Cellular Biology, 1994-11, Vol.14 (11), p.7483-7491

1994

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Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Nature medicine, 2009-11, Vol.15 (11), p.1333-1333

2009

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The Proteasome Inhibitor PR-171 Inhibits Cell Growth, Induces Apoptosis, and Overcomes De Novo and Acquired Drug Resistance in Human Multiple Myeloma Cells

Blood, 2005-11, Vol.106 (11), p.1575-1575

2005

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Identification of Peptide Epoxy-Ketone Proteasome Inhibitors with Differential Active Site Selectivity

Blood, 2006-11, Vol.108 (11), p.4398-4398

2006

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The Novel, Irreversible Proteasome Inhibitor PR-171 Demonstrates Potent Anti-Tumor Activity in Pre-Clinical Models of Multiple Myeloma, and Overcomes Bortezomib Resistance

Blood, 2006-11, Vol.108 (11), p.3461-3461

2006

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Potent Activity of a Novel, Irreversible Inhibitor of the Ubiquitin-Proteasome Pathway Against Pre-Clinical Models of Multiple Myeloma

Blood, 2005-11, Vol.106 (11), p.1576-1576

2005

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A Proteasome Specific Binding Assay for Quantitation of Constitutive and Immunoproteasome Active Sites

Blood, 2005-11, Vol.106 (11), p.2472-2472

2005

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Pharmacokinetics, Pharmacodynamics and Anti-Tumor Efficacy of PR-171, a Novel Inhibitor of the 20S Proteasome

Blood, 2005-11, Vol.106 (11), p.609-609

2005

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Biochemical and Cellular Characterization of the Novel Proteasome Inhibitor PR-171

Blood, 2005-11, Vol.106 (11), p.1588-1588

2005

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Nigrostriatal lesion alters neurophysiological responses to selective and nonselective D-1 and D-2 dopamine agonists in rat globus pallidus

Synapse (New York, N.Y.), 1990, Vol.5 (2), p.83-93

1990

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Acute reduction of dopamine levels alters responses of basal ganglia neurons to selective D-1 and D-2 dopamine receptor stimulation

European journal of pharmacology, 1988-08, Vol.152 (3), p.289-300

1988

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ralGDS Family Members Interact with the Effector Loop of ras p21

Molecular and cellular biology, 1994-11, Vol.14 (11), p.7483-7491

1994

Volltextzugriff (PDF)

POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies

American journal of human genetics, 2023-05, Vol.110 (5), p.809-825

2023

Volltextzugriff (PDF)

Weight Change During the Postintervention Follow-up of Look AHEAD

Diabetes care, 2022-06, Vol.45 (6), p.1306-1314

2022

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Drug discovery in the ubiquitin regulatory pathway

Drug Discovery Today, 2003-08, Vol.8 (16), p.746-754

2003

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

Validation of the Proteasome as a Therapeutic Target in Plasmodium Using an Epoxyketone Inhibitor with Parasite-Specific Toxicity

The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

Cell cycle regulatory E3 ubiquitin ligases as anticancer targets

A Novel Splice Variant of the Cell Death-promoting Protein BAX

Abstract 1416: CB-839, a novel potent and selective glutaminase inhibitor, has broad antiproliferative activity in cell lines derived from both solid tumors and hematological malignancies

ralGDS family members interact with the effector loop of ras p21

Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

The Proteasome Inhibitor PR-171 Inhibits Cell Growth, Induces Apoptosis, and Overcomes De Novo and Acquired Drug Resistance in Human Multiple Myeloma Cells

Identification of Peptide Epoxy-Ketone Proteasome Inhibitors with Differential Active Site Selectivity

The Novel, Irreversible Proteasome Inhibitor PR-171 Demonstrates Potent Anti-Tumor Activity in Pre-Clinical Models of Multiple Myeloma, and Overcomes Bortezomib Resistance

Potent Activity of a Novel, Irreversible Inhibitor of the Ubiquitin-Proteasome Pathway Against Pre-Clinical Models of Multiple Myeloma

A Proteasome Specific Binding Assay for Quantitation of Constitutive and Immunoproteasome Active Sites

Pharmacokinetics, Pharmacodynamics and Anti-Tumor Efficacy of PR-171, a Novel Inhibitor of the 20S Proteasome

Biochemical and Cellular Characterization of the Novel Proteasome Inhibitor PR-171

Nigrostriatal lesion alters neurophysiological responses to selective and nonselective D-1 and D-2 dopamine agonists in rat globus pallidus

Acute reduction of dopamine levels alters responses of basal ganglia neurons to selective D-1 and D-2 dopamine receptor stimulation

ralGDS Family Members Interact with the Effector Loop of ras p21

POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies

Weight Change During the Postintervention Follow-up of Look AHEAD

Drug discovery in the ubiquitin regulatory pathway

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