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Protein tyrosine phosphatase 1B in metabolic diseases and drug development

Nature reviews. Endocrinology, 2024-06, Vol.20 (6), p.366-378

2024

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Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Cancer research (Chicago, Ill.), 2018-01, Vol.78 (1), p.75-87

2018

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Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR−/− mice

Scientific reports, 2023-03, Vol.13 (1), p.3937-16, Article 3937

2023

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Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy

Gene therapy, 2024-09, Vol.31 (9-10), p.445-454

2024

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Effects of dietary restriction on metabolic and cognitive health

Proceedings of the Nutrition Society, 2021-05, Vol.80 (2), p.126-138

2021

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Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

Biochemical journal, 2011-09, Vol.438 (2), p.369-378

2011

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Ablation of Bscl2 /seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Disease models & mechanisms, 2020-01, Vol.13 (1)

2020

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The effect of the shape of a clip on the magnetic field during magnetic resonance imaging examinations

Medicinski glasnik, 2022-02, Vol.19 (1)

2022

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CT advantages of potential use of polymer plastic clips in neurocranium

Medicinski glasnik, 2023-02, Vol.20 (1), p.77-82

2023

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Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy

Molecular therapy. Methods & clinical development, 2022-12, Vol.27, p.206-216

2022

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Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Molecular metabolism (Germany), 2018-04, Vol.10, p.55-65

2018

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Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

Scientific reports, 2018-12, Vol.8 (1), p.17863-11, Article 17863

2018

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Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

Scientific reports, 2017-03, Vol.7 (1), p.43782, Article 43782

2017

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Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

PloS one, 2012-02, Vol.7 (2), p.e32700-e32700

2012

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Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Biochemical pharmacology, 2016-01, Vol.100, p.86-97

2016

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Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

Biochemical pharmacology, 2014-12, Vol.92 (4), p.607-617

2014

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The Role of Inflammation in Diabetic Retinopathy

Frontiers in immunology, 2020-11, Vol.11, p.583687-583687

2020

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Intraarticular steroids in treatment of juvenile idiopathic arthritis: A single center experience

Sanamed, 2021-05, Vol.16 (1), p.41-46

2021

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Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy

Journal of clinical medicine, 2021-01, Vol.10 (3), p.441

2021

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Impact of diabetes on COVID‐19 mortality and hospital outcomes from a global perspective: An umbrella systematic review and meta‐analysis

Endocrinology, diabetes & metabolism, 2022-05, Vol.5 (3), p.e00338-n/a

2022

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Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis

PloS one, 2012-05, Vol.7 (5)

2012

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The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet

Cellular and molecular life sciences : CMLS, 2021-03, Vol.78 (6), p.3045-3055

2021

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Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance

Diabetologia, 2024-10

2024

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Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia

Molecular neurobiology, 2020-01, Vol.57 (1), p.539-550

2020

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The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5970

2021

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Protein tyrosine phosphatase 1B in metabolic diseases and drug development

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR−/− mice

Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy

Effects of dietary restriction on metabolic and cognitive health

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

Ablation of Bscl2 /seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

The effect of the shape of a clip on the magnetic field during magnetic resonance imaging examinations

CT advantages of potential use of polymer plastic clips in neurocranium

Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

The Role of Inflammation in Diabetic Retinopathy

Intraarticular steroids in treatment of juvenile idiopathic arthritis: A single center experience

Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy

Impact of diabetes on COVID‐19 mortality and hospital outcomes from a global perspective: An umbrella systematic review and meta‐analysis

Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis

The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet

Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance

Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia

The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition

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