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microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes

Archives of toxicology, 2022-07, Vol.96 (7), p.2033-2047

2022

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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

Clinical and translational science, 2021-05, Vol.14 (3), p.1133-1146

2021

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A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function

Endocrinology (Philadelphia), 2005-09, Vol.146 (9), p.3696-3701

2005

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Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study

Pharmacology research & perspectives, 2023-02, Vol.11 (1), p.e01059-n/a

2023

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Repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.117-129

2009

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Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog

Regulatory toxicology and pharmacology, 2013-12, Vol.67 (3), p.351-359

2013

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Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107537, Article 107537

2024

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“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107269-107269, Article 107269

2023

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Are drugs marketed nowadays more selective and safe than those approved 20 years ago?

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.106999, Article 106999

2021

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Identification of pharmacological targets involved in drug-induced thermoregulation impairment

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107008, Article 107008

2021

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Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107297-107297, Article 107297

2023

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A practical guide to secondary pharmacology in drug discovery

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106869-106869, Article 106869

2020

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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors

Toxicological sciences, 2024-07

2024

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Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials

Toxicological sciences, 2024-07

2024

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The state of the art in secondary pharmacology and its impact on the safety of new medicines

Nature reviews. Drug discovery, 2024-07, Vol.23 (7), p.525-545

2024

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Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107052, Article 107052

2021

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Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107023, Article 107023

2021

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Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines

Nature reviews. Drug discovery, 2024-07, Vol.23 (7), p.563-563

2024

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Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices

Clinical pharmacology and therapeutics, 2024-07, Vol.116 (1), p.106-116

2024

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Variability in cardiac ion channel assays: A major challenge for CiPA paradigm implementation

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.341-342

2016

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Comparison of four in silico models to predict cardiac action potential effects and proarrhythmia liability

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.350-350

2016

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Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107042-107042, Article 107042

2021

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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.14121-14143

2022

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Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107270-107270, Article 107270

2023

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Development of predictive inotropy in silico cardiac safety assay for drug candidate screening

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107046, Article 107046

2021

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microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function

Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study

Repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat

Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog

Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis

“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead

Are drugs marketed nowadays more selective and safe than those approved 20 years ago?

Identification of pharmacological targets involved in drug-induced thermoregulation impairment

Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability

A practical guide to secondary pharmacology in drug discovery

Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors

Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials

The state of the art in secondary pharmacology and its impact on the safety of new medicines

Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study

Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?

Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines

Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices

Variability in cardiac ion channel assays: A major challenge for CiPA paradigm implementation

Comparison of four in silico models to predict cardiac action potential effects and proarrhythmia liability

Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As

Development of predictive inotropy in silico cardiac safety assay for drug candidate screening

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