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microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes

Archives of toxicology, 2022-07, Vol.96 (7), p.2033-2047

2022

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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

Clinical and translational science, 2021-05, Vol.14 (3), p.1133-1146

2021

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Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project

Journal of pharmacological and toxicological methods, 2020-07, Vol.104, p.106874-106874, Article 106874

2020

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A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function

Endocrinology (Philadelphia), 2005-09, Vol.146 (9), p.3696-3701

2005

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Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study

Pharmacology research & perspectives, 2023-02, Vol.11 (1), p.e01059-n/a

2023

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Repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.117-129

2009

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Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog

Regulatory toxicology and pharmacology, 2013-12, Vol.67 (3), p.351-359

2013

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Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107537, Article 107537

2024

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“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107269-107269, Article 107269

2023

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Identification of pharmacological targets involved in drug-induced thermoregulation impairment

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107008, Article 107008

2021

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Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107297-107297, Article 107297

2023

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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors

Toxicological sciences, 2024-07

2024

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Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials

Toxicological sciences, 2024-07

2024

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A practical guide to secondary pharmacology in drug discovery

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106869-106869, Article 106869

2020

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Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107023, Article 107023

2021

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Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107052, Article 107052

2021

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Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines

Nature reviews. Drug discovery, 2024-07, Vol.23 (7), p.563-563

2024

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Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices

Clinical pharmacology and therapeutics, 2024-07, Vol.116 (1), p.106-116

2024

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The state of the art in secondary pharmacology and its impact on the safety of new medicines

Nature reviews. Drug discovery, 2024-05, Vol.23 (7), p.525-545

2024

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Variability in cardiac ion channel assays: A major challenge for CiPA paradigm implementation

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.341-342

2016

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Comparison of four in silico models to predict cardiac action potential effects and proarrhythmia liability

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.350-350

2016

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Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107042-107042, Article 107042

2021

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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.14121-14143

2022

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A cross-species comparison study of undesired drug-induced hypothermia using telemetry

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107002, Article 107002

2021

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Development of predictive inotropy in silico cardiac safety assay for drug candidate screening

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107046, Article 107046

2021

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microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project

A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function

Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study

Repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat

Hydroxypropyl-β-cyclodextrin impacts renal and systemic hemodynamics in the anesthetized dog

Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis

“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead

Identification of pharmacological targets involved in drug-induced thermoregulation impairment

Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability

Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors

Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials

A practical guide to secondary pharmacology in drug discovery

Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?

Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study

Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines

Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices

The state of the art in secondary pharmacology and its impact on the safety of new medicines

Variability in cardiac ion channel assays: A major challenge for CiPA paradigm implementation

Comparison of four in silico models to predict cardiac action potential effects and proarrhythmia liability

Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

A cross-species comparison study of undesired drug-induced hypothermia using telemetry

Development of predictive inotropy in silico cardiac safety assay for drug candidate screening

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