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Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

eLife, 2019-12, Vol.8

2019

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Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias

British journal of pharmacology, 2019-10, Vol.176 (19), p.3819-3833

2019

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What determines the optimal pharmacological treatment of atrial fibrillation? Insights from in silico trials in 800 virtual atria

The Journal of physiology, 2023-09, Vol.601 (18), p.4013-4032

2023

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Fourier spectral methods for fractional-in-space reaction-diffusion equations

BIT Numerical Mathematics, 2014-12, Vol.54 (4), p.937-954

2014

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Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

Journal of the Royal Society interface, 2014-08, Vol.11 (97), p.20140352

2014

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Toward a broader view of mechanisms of drug cardiotoxicity

Cell reports. Medicine, 2021-03, Vol.2 (3), p.100216, Article 100216

2021

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Commentary: Atrial Rotor Dynamics Under Complex Fractional Order Diffusion

Frontiers in physiology, 2018-10, Vol.9, p.1386-1386

Bueno-Orovio, Alfonso

2018

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Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (23), p.E2098-E2105

2013

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On the Order of the Fractional Laplacian in Determining the Spatio-Temporal Evolution of a Space-Fractional Model of Cardiac Electrophysiology

PloS one, 2015-12, Vol.10 (12), p.e0143938-e0143938

2015

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Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Frontiers in physiology, 2017-09, Vol.8, p.668

2017

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Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

Progress in biophysics and molecular biology, 2016-01, Vol.120 (1-3), p.115-127

2016

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Multiscale Modelling of β-Adrenergic Stimulation in Cardiac Electromechanical Function

Mathematics (Basel), 2021-08, Vol.9 (15), p.1785

2021

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Dual Transcriptomic and Molecular Machine Learning Predicts all Major Clinical Forms of Drug Cardiotoxicity

Frontiers in pharmacology, 2020-05, Vol.11, p.639

2020

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Strategies of data layout and cache writing for input-output optimization in high performance scientific computing: Applications to the forward electrocardiographic problem

PloS one, 2018-08, Vol.13 (8), p.e0202410-e0202410

2018

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General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

Clinical pharmacology and therapeutics, 2020-01, Vol.107 (1), p.102-111

2020

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In-silico drug trials for precision medicine in atrial fibrillation: From ionic mechanisms to electrocardiogram-based predictions in structurally-healthy human atria

Frontiers in physiology, 2022-09, Vol.13, p.966046-966046

2022

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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy

Scientific reports, 2022-12, Vol.12 (1), p.22501-22501, Article 22501

2022

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Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

Frontiers in pharmacology, 2020-01, Vol.10, p.1643

2020

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The Electrogenic Na + /K + Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Frontiers in physiology, 2017-05, Vol.8, p.278-278

2017

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Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation

Frontiers in physiology, 2018-08, Vol.9, p.1114-1114

2018

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Spectral smoothed boundary methods: The role of external boundary conditions

Numerical methods for partial differential equations, 2006-03, Vol.22 (2), p.435-448

2006

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Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

Frontiers in physiology, 2019-03, Vol.10, p.259-259

2019

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An Automata-Based Cardiac Electrophysiology Simulator to Assess Arrhythmia Inducibility

Mathematics (Basel), 2022-04, Vol.10 (8), p.1293

2022

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The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue

American journal of physiology. Heart and circulatory physiology, 2012-03, Vol.302 (5), p.H1146-H1159

2012

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Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias

What determines the optimal pharmacological treatment of atrial fibrillation? Insights from in silico trials in 800 virtual atria

Fourier spectral methods for fractional-in-space reaction-diffusion equations

Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

The 'Digital Twin' to enable the vision of precision cardiology

Toward a broader view of mechanisms of drug cardiotoxicity

Commentary: Atrial Rotor Dynamics Under Complex Fractional Order Diffusion

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

On the Order of the Fractional Laplacian in Determining the Spatio-Temporal Evolution of a Space-Fractional Model of Cardiac Electrophysiology

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

Multiscale Modelling of β-Adrenergic Stimulation in Cardiac Electromechanical Function

Dual Transcriptomic and Molecular Machine Learning Predicts all Major Clinical Forms of Drug Cardiotoxicity

Strategies of data layout and cache writing for input-output optimization in high performance scientific computing: Applications to the forward electrocardiographic problem

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

In-silico drug trials for precision medicine in atrial fibrillation: From ionic mechanisms to electrocardiogram-based predictions in structurally-healthy human atria

Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

The Electrogenic Na + /K + Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation

Spectral smoothed boundary methods: The role of external boundary conditions

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

An Automata-Based Cardiac Electrophysiology Simulator to Assess Arrhythmia Inducibility

The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue

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