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A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?

International journal of molecular sciences, 2021-03, Vol.22 (5), p.2721

2021

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Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review

International journal of molecular sciences, 2021-04, Vol.22 (7), p.3670

2021

Volltextzugriff (PDF)

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition

Frontiers in cardiovascular medicine, 2020-12, Vol.7, p.622473

2020

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State of play and clinical prospects of antibody gene transfer

Journal of translational medicine, 2017-06, Vol.15 (1), p.131-131, Article 131

2017

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The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo

Thrombosis research, 2012-10, Vol.130 (4), p.576-585

2012

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Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

International journal of molecular sciences, 2021-02, Vol.22 (3), p.1482

2021

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Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding

Blood, 2018-10, Vol.132 (15), p.1593-1603

2018

Volltextzugriff (PDF)

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice

Stroke (1970), 2016-09, Vol.47 (9), p.2419-2422

2016

Volltextzugriff (PDF)

Produits biologiques et biosimilaires: science et implications

Journal de pharmacie clinique, 2013, Vol.32 (1), p.17-22

DECLERCK, Paul J

2013

Volltextzugriff (PDF)

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

International journal of molecular sciences, 2020-08, Vol.21 (16), p.5859

2020

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Prevention of Serpin Misfolding by RNA Aptamers

Cell chemical biology, 2016-06, Vol.23 (6), p.639-640

2016

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Biologicals and biosimilars: a review of the science and its implications

GaBI Journal, 2012-03, Vol.1 (1), p.13-16

Declerck, Paul J

2012

Volltextzugriff (PDF)

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Scientific reports, 2017-06, Vol.7 (1), p.3385-11, Article 3385

2017

Volltextzugriff (PDF)

Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin

Seminars in thrombosis and hemostasis, 2013-06, Vol.39 (4), p.356

2013

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Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor

Arteriosclerosis, thrombosis, and vascular biology, 2012-02, Vol.32 (2), p.427

2012

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PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

Nature medicine, 2014-07, Vol.20 (7), p.741-747

2014

Volltextzugriff (PDF)

Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin

PloS one, 2018-05, Vol.13 (5), p.e0196911-e0196911

2018

Volltextzugriff (PDF)

Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model

Blood, 2011-04, Vol.117 (17), p.4615-4622

2011

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The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

The FASEB journal, 2002-02, Vol.16 (2), p.147-154

2002

Volltextzugriff (PDF)

Active PAI-1 as marker for venous thromboembolism: Case–control study using a comprehensive panel of PAI-1 and TAFI assays

Thrombosis research, 2014-11, Vol.134 (5), p.1097-1102

2014

Volltextzugriff (PDF)

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor

Circulation (New York, N.Y.), 2011-10, Vol.124 (17), p.1848-1859

2011

Volltextzugriff (PDF)

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury

PloS one, 2013-02, Vol.8 (2), p.e55262-e55262

2013

Volltextzugriff (PDF)

Biosimilar monoclonal antibodies: a science-based regulatory challenge

Expert opinion on biological therapy, 2013-02, Vol.13 (2), p.153-156

Declerck, Paul J

2013

Volltextzugriff (PDF)

Plasminogen activator inhibitor-1 modulates adipocyte differentiation

American journal of physiology: endocrinology and metabolism, 2006-01, Vol.290 (1), p.E103-E113

2006

Volltextzugriff (PDF)

Novel or expanding current targets in fibrinolysis

Drug discovery today, 2014-09, Vol.19 (9), p.1476-1482

2014

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A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?

Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition

State of play and clinical prospects of antibody gene transfer

The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo

Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice

Produits biologiques et biosimilaires: science et implications

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

Prevention of Serpin Misfolding by RNA Aptamers

Biologicals and biosimilars: a review of the science and its implications

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin

Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor

PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin

Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model

The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

Active PAI-1 as marker for venous thromboembolism: Case–control study using a comprehensive panel of PAI-1 and TAFI assays

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury

Biosimilar monoclonal antibodies: a science-based regulatory challenge

Plasminogen activator inhibitor-1 modulates adipocyte differentiation

Novel or expanding current targets in fibrinolysis

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