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Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

Antimicrobial Agents and Chemotherapy, 2011-10, Vol.55 (10), p.4552-4559

2011

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Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics

PloS one, 2013-10, Vol.8 (10), p.e77448

2013

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Prevalent Polymorphisms in Wild-Type HIV-1 Integrase Are Unlikely To Engender Drug Resistance to Dolutegravir (S/GSK1349572)

Antimicrobial Agents and Chemotherapy, 2013-03, Vol.57 (3), p.1379-1384

2013

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Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

Bioorganic & medicinal chemistry, 2003-07, Vol.11 (13), p.2663-2676

2003

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.360-364

2009

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Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling

Molecular cancer therapeutics, 2024-01, Vol.23 (1), p.35-46

2024

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Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK

Science signaling, 2022-05, Vol.15 (736), p.eabg5216

2022

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Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation

The Journal of biological chemistry, 2014-06, Vol.289 (23), p.16270-16277

2014

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Kinase-Targeted Library Design through the Application of the PharmPrint Methodology

Journal of Chemical Information and Modeling, 2008-12, Vol.48 (12), p.2395-2403

2008

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Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6470-6475

2011

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Discovery of Bioavailable 4,4-Disubstituted Piperidines as Potent Ligands of the Chemokine Receptor 5 and Inhibitors of the Human Immunodeficiency Virus-1

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6538-6546

2008

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Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3136-3140

2009

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.469-473

2009

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Aza-stilbenes as potent and selective c-RAF inhibitors

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5378-5383

2006

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Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.373-377

2009

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Application of the PharmPrint Methodology to Two Protein Kinases

Journal of Chemical Information and Computer Sciences, 2004-09, Vol.44 (5), p.1803-1809

2004

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Development and application of software tools for computer -assisted drug design

Deanda, Felix

1999

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Dolutegravir Interactions with HIV-1 Integrase-DNA: Structural Rationale for Drug Resistance and Dissociation Kinetics: e77448

PloS one, 2013-10, Vol.8 (10)

2013

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GSSI, a General Model for Solute−Solvent Interactions. 1. Description of the Model

Molecular pharmaceutics, 2004-01, Vol.1 (1), p.23-39

2004

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Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.373-377

2009

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Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (11), p.3136-3140

2009

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Discovery of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.469-473

2009

Volltextzugriff (PDF)

Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Corrigendum to “Recent Progress in Discovery of Small–Molecule CCR5 Chemokine Receptor Ligands as HIV-1 Inhibitors” [ Bioorg. Med. Chem.2003, 11, 2663–2676]

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (18), p.4155-4155

2003

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Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics

Prevalent Polymorphisms in Wild-Type HIV-1 Integrase Are Unlikely To Engender Drug Resistance to Dolutegravir (S/GSK1349572)

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK

Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation

Kinase-Targeted Library Design through the Application of the PharmPrint Methodology

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

Discovery of Bioavailable 4,4-Disubstituted Piperidines as Potent Ligands of the Chemokine Receptor 5 and Inhibitors of the Human Immunodeficiency Virus-1

Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Aza-stilbenes as potent and selective c-RAF inhibitors

Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Application of the PharmPrint Methodology to Two Protein Kinases

Development and application of software tools for computer -assisted drug design

Dolutegravir Interactions with HIV-1 Integrase-DNA: Structural Rationale for Drug Resistance and Dissociation Kinetics: e77448

GSSI, a General Model for Solute−Solvent Interactions. 1. Description of the Model

Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Discovery of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase

Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Corrigendum to “Recent Progress in Discovery of Small–Molecule CCR5 Chemokine Receptor Ligands as HIV-1 Inhibitors” [ Bioorg. Med. Chem.2003, 11, 2663–2676]

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