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2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4261-4264

2007

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Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4467-4471

2003

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Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of (S)-2,3-Dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5303-5310

2002

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Aldose Reductase as a Target for Drug Design: Molecular Modeling Calculations on the Binding of Acyclic Sugar Substrates to the Enzyme

Biochemistry (Easton), 1995-07, Vol.34 (26), p.8299-8308

1995

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Tripeptidyl-peptidase II (TPP II) inhibitory activity of ( S )-2,3-dihydro-2-(1 H -imidazol-2-yl)-1 H -indoles, a systematic SAR evaluation. Part 2

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4467-4471

2003

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Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of ( S )-2,3-Dihydro-2-(4-alkyl-1 H -imidazol-2-yl)-1 H -indoles

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5303-5310

2002

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(+)-(2R-cis)-Dimethyl(10-bromo-2,3,3a,8-tetrahydrodibenz[c,f]isoxazolo[2,3-a]azepin-2-ylmethyl)amine

Acta crystallographica. Section C, Crystal structure communications, 1999-05, Vol.55 (5), p.794-796

1999

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Molecular modelling calculations on the binding of D- and L-xylose to wild-type aldose reductase and its H110Q and H110A mutants

Advances in experimental medicine and biology, 1995, Vol.372, p.223

1995

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Tripeptidyl-Peptidase II (TPP II) Inhibitory Activity of (S)-2,3-Dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a Systematic SAR Evaluation. Part 2

ChemInform, 2004-03, Vol.35 (12), p.no-no

2004

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A functional CFTR assay using primary cystic fibrosis intestinal organoids

Nature medicine, 2013-07, Vol.19 (7), p.939-945

2013

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CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Cell stem cell, 2020-04, Vol.26 (4), p.503-510.e7

2020

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Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease

Journal of Crohn's and colitis, 2014-10, Vol.8 (10), p.1179-1207

2014

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Failure of working memory training to enhance cognition or intelligence

PloS one, 2013-05, Vol.8 (5), p.e63614-e63614

2013

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Multicomponent Prehabilitation as a Novel Strategy for Preventing Delirium in Older Chronic Limb Threatening Ischemia Patients: A Study Protocol

Clinical interventions in aging, 2022-05, Vol.17, p.767-776

2022

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Heart failure with preserved, mid‐range, and reduced ejection fraction across health care settings: an observational study

ESC Heart Failure, 2022-02, Vol.9 (1), p.363-372

2022

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A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Nature genetics, 2005-09, Vol.37 (9), p.958-963

2005

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In vivo comparison of 2′-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping

The journal of gene medicine, 2009-03, Vol.11 (3), p.257-266

2009

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Developing a framework for evaluation: a Theory of Change for complex workplace mental health interventions

BMC public health, 2023-06, Vol.23 (1), p.1171-1171, Article 1171

2023

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Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial

JAMA : the journal of the American Medical Association, 2014-04, Vol.311 (15), p.1526

2014

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Major depressive disorder is associated with changes in a cluster of serum and urine biomarkers

Journal of psychosomatic research, 2019-10, Vol.125, p.109796-109796, Article 109796

2019

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A novel ubiquitin ligase is deficient in Fanconi anemia

Nature genetics, 2003-10, Vol.35 (2), p.165-170

2003

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Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

Science (American Association for the Advancement of Science), 2024-05, Vol.384 (6699), p.eadd6260

2024

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2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2

Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of (S)-2,3-Dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles

Aldose Reductase as a Target for Drug Design: Molecular Modeling Calculations on the Binding of Acyclic Sugar Substrates to the Enzyme

Tripeptidyl-peptidase II (TPP II) inhibitory activity of ( S )-2,3-dihydro-2-(1 H -imidazol-2-yl)-1 H -indoles, a systematic SAR evaluation. Part 2

Design, Synthesis, and Tripeptidyl Peptidase II Inhibitory Activity of a Novel Series of ( S )-2,3-Dihydro-2-(4-alkyl-1 H -imidazol-2-yl)-1 H -indoles

(+)-(2R-cis)-Dimethyl(10-bromo-2,3,3a,8-tetrahydrodibenz[c,f]isoxazolo[2,3-a]azepin-2-ylmethyl)amine

Molecular modelling calculations on the binding of D- and L-xylose to wild-type aldose reductase and its H110Q and H110A mutants

Tripeptidyl-Peptidase II (TPP II) Inhibitory Activity of (S)-2,3-Dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a Systematic SAR Evaluation. Part 2

A functional CFTR assay using primary cystic fibrosis intestinal organoids

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease

Failure of working memory training to enhance cognition or intelligence

Multicomponent Prehabilitation as a Novel Strategy for Preventing Delirium in Older Chronic Limb Threatening Ischemia Patients: A Study Protocol

Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

Heart failure with preserved, mid‐range, and reduced ejection fraction across health care settings: an observational study

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

In vivo comparison of 2′-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Developing a framework for evaluation: a Theory of Change for complex workplace mental health interventions

Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial

Major depressive disorder is associated with changes in a cluster of serum and urine biomarkers

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

A novel ubiquitin ligase is deficient in Fanconi anemia

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

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