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Huntington's disease: from pathology and genetics to potential therapies

Biochemical journal, 2008-06, Vol.412 (2), p.191-209

2008

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Regulation of mammalian autophagy in physiology and pathophysiology

Physiological reviews, 2010-10, Vol.90 (4), p.1383-1435

2010

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Nature genetics, 2004-06, Vol.36 (6), p.585-595

2004

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Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

The Journal of biological chemistry, 2007-02, Vol.282 (8), p.5641-5652

2007

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Cystamine suppresses polyalanine toxicity in a mouse model of oculopharyngeal muscular dystrophy

Science translational medicine, 2010-06, Vol.2 (34), p.34ra40

2010

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Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice

Nature medicine, 2005-06, Vol.11 (6), p.672-677

2005

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Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation

Human molecular genetics, 2008-04, Vol.17 (8), p.1097-1108

2008

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Self- versus parent-ratings of industriousness, affect, and life satisfaction in relation to academic outcomes

British journal of educational psychology, 2014-06, Vol.84 (2), p.281-293

2014

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Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

Human molecular genetics, 2006-01, Vol.15 (1), p.23-31

2006

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

The Journal of cell biology, 2005-05, Vol.169 (4), p.647-656

2005

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Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy

Human molecular genetics, 2011-03, Vol.20 (6), p.1154-1163

2011

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Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres

Human molecular genetics, 2010-06, Vol.19 (11), p.2191-2207

2010

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The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

BMC biochemistry, 2007-11, Vol.8 Suppl 1 (S1), p.S2-S2, Article S2

2007

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Oculopharyngeal muscular dystrophy: Potential therapies for an aggregate-associated disorder

The international journal of biochemistry & cell biology, 2006, Vol.38 (9), p.1457-1462

2006

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Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion

Human molecular genetics, 2006-02, Vol.15 (3), p.453-465

2006

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Surveying Medical Information across Europe: The Present and the Future

Drug information journal, 2009-11, Vol.43 (6), p.637-654

2009

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases

The Journal of cell biology, 2005-05, Vol.169 (4), p.647-656

2005

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Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and Î±-Synuclein

The Journal of biological chemistry, 2007-02, Vol.282 (8), p.5641

2007

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U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection

The New England journal of medicine, 2005-03, Vol.352 (9), p.865-874

2005

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A Randomized Controlled Trial of Two Different Macronutrient Profiles on Weight, Body Composition and Metabolic Parameters in Obese Adolescents Seeking Weight Loss

PloS one, 2016-03, Vol.11 (3), p.e0151787-e0151787

2016

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Renal staffs’ understanding of patients’ experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia

PloS one, 2021-07, Vol.16 (7), p.e0254931-e0254931

2021

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Tourism and the smartphone app: capabilities, emerging practice and scope in the travel domain

Current issues in tourism, 2014-01, Vol.17 (1), p.84-101

2014

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The workplace masking experiences of autistic, non-autistic neurodivergent and neurotypical adults in the UK

PloS one, 2023-09, Vol.18 (9), p.e0290001

2023

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WHO/IUIS Allergen Nomenclature: Providing a common language

Molecular immunology, 2018-08, Vol.100, p.3-13

2018

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Huntington's disease: from pathology and genetics to potential therapies

Regulation of mammalian autophagy in physiology and pathophysiology

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Cystamine suppresses polyalanine toxicity in a mouse model of oculopharyngeal muscular dystrophy

Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice

Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation

Self- versus parent-ratings of industriousness, affect, and life satisfaction in relation to academic outcomes

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy

Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

Oculopharyngeal muscular dystrophy: Potential therapies for an aggregate-associated disorder

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion

Surveying Medical Information across Europe: The Present and the Future

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and Î±-Synuclein

U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection

A Randomized Controlled Trial of Two Different Macronutrient Profiles on Weight, Body Composition and Metabolic Parameters in Obese Adolescents Seeking Weight Loss

Renal staffs’ understanding of patients’ experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia

Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis

Tourism and the smartphone app: capabilities, emerging practice and scope in the travel domain

The workplace masking experiences of autistic, non-autistic neurodivergent and neurotypical adults in the UK

WHO/IUIS Allergen Nomenclature: Providing a common language

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