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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.E3445-E3454

2013

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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9401-9417

2023

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Abstract LB-304: ATSP-9172, a novel Stapled Peptide inhibitor of HIF-dependent transcriptional activity with in vivo antitumor efficacy in a preclinical model of prostate cancer

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.LB-304-LB-304

2013

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Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats

Peptides (New York, N.Y. : 1980), 2008-08, Vol.29 (8), p.1362-1368

2008

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Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.14519-14519

2013

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Stapled [alpha]-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.E3445

2013

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Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-I

Domestic animal endocrinology, 2009-04, Vol.36 (3), p.162-172

2009

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Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

Nature (London), 1996-04, Vol.380 (6576), p.720-723

1996

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CHAPTER 9 - Macrocyclic α-Helical Peptide Drug Discovery

Macrocycles in drug discovery, 2015, p.339-366

2015

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Shedding of the Lymphocyte L-Selectin Adhesion Molecule Is Inhibited by a Hydroxamic Acid-based Protease Inhibitor

The Journal of biological chemistry, 1996-03, Vol.271 (12), p.7019-7024

1996

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Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor. Identification with an L-selectin-alkaline phosphatase reporter

The Journal of biological chemistry, 1996-03, Vol.271 (12), p.7019-7024

1996

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An approach to cyclic peptide libraries: Reducing epimerization in medium sized rings during solid phase synthesis

Tetrahedron letters, 1996-01, Vol.37 (5), p.591-594

1996

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Effect of ghrelin on activities of some lysosomal hydrolases in rabbits

Neuro-endocrinology letters, 2005-08, Vol.26 (4), p.397-400

2005

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Prof. Arno F. Spatola's founding role at Peptides International

The journal of peptide research, 2004-02, Vol.63 (2), p.52-55

2004

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Macrocyclic α-Helical Peptide Drug Discovery

Macrocycles in Drug Discovery, 2014

Levin, Jeremy

2014

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Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid

The Journal of biological chemistry, 1990-03, Vol.265 (9), p.5199-5205

1990

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Amide bond surrogates: pseudopeptides and macrocycles

Tetrahedron, 1988, Vol.44 (3), p.821-833

1988

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Discoordinate expression of the yeast mitochondrial ribosomal protein MRP1

The Journal of biological chemistry, 1990-05, Vol.265 (13), p.7449-7454

1990

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Assessment of biological activity of synthetic fragments of transforming growth factor-alpha

Journal of cellular biochemistry, 1988-04, Vol.36 (4), p.341-352

1988

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Highly potent side chain-main chain cyclized dermorphin-deltorphin analogues: An integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling

Journal of peptide science, 1995-05, Vol.1 (3), p.157-174

1995

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Dermorphin analogs: Resistance to in vitro enzymatic degradation is not always increased by additional D-amino acid substitutions

Biochemical and biophysical research communications, 1988-10, Vol.156 (1), p.125-130

1988

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ChemInform Abstract: Applications of CLEAR Resin for Solid Phase Organic Synthesis: Comparison with Polystyrene Based Resin

ChemInform, 2000-06, Vol.31 (23), p.no-no

2000

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Preferred solution and calculated conformations of dermorphin and analysis of structure-conformation-activity relationships in the series [A1an]-dermorphin

Biopolymers, 1985-12, Vol.24 (12), p.2417-2430

1985

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Structure-activity studies of dermorphin. Synthesis and some pharmacological data of dermorphin and its 1-substituted analogs

Journal of medicinal chemistry, 1983-10, Vol.26 (10), p.1445-1447

1983

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Arginine-vasopressin analogs with high antidiuretic/vasopressor selectivity. Synthesis, biological activity and receptor binding affinity of arginine-vasopressin analogs with substitutions in positions 1, 2, 4, 7, and 8

Journal of medicinal chemistry, 1986-01, Vol.29 (1), p.96-99

1986

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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development

Abstract LB-304: ATSP-9172, a novel Stapled Peptide inhibitor of HIF-dependent transcriptional activity with in vivo antitumor efficacy in a preclinical model of prostate cancer

Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats

Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Stapled [alpha]-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-I

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

CHAPTER 9 - Macrocyclic α-Helical Peptide Drug Discovery

Shedding of the Lymphocyte L-Selectin Adhesion Molecule Is Inhibited by a Hydroxamic Acid-based Protease Inhibitor

Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor. Identification with an L-selectin-alkaline phosphatase reporter

An approach to cyclic peptide libraries: Reducing epimerization in medium sized rings during solid phase synthesis

Effect of ghrelin on activities of some lysosomal hydrolases in rabbits

Prof. Arno F. Spatola's founding role at Peptides International

Macrocyclic α-Helical Peptide Drug Discovery

Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid

Amide bond surrogates: pseudopeptides and macrocycles

Discoordinate expression of the yeast mitochondrial ribosomal protein MRP1

Assessment of biological activity of synthetic fragments of transforming growth factor-alpha

Highly potent side chain-main chain cyclized dermorphin-deltorphin analogues: An integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling

Dermorphin analogs: Resistance to in vitro enzymatic degradation is not always increased by additional D-amino acid substitutions

ChemInform Abstract: Applications of CLEAR Resin for Solid Phase Organic Synthesis: Comparison with Polystyrene Based Resin

Preferred solution and calculated conformations of dermorphin and analysis of structure-conformation-activity relationships in the series [A1an]-dermorphin

Structure-activity studies of dermorphin. Synthesis and some pharmacological data of dermorphin and its 1-substituted analogs

Arginine-vasopressin analogs with high antidiuretic/vasopressor selectivity. Synthesis, biological activity and receptor binding affinity of arginine-vasopressin analogs with substitutions in positions 1, 2, 4, 7, and 8

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