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Multidrug resistance-associated proteins: expression and function in the central nervous system

Pharmacological reviews, 2006-06, Vol.58 (2), p.140

2006

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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance

Drug metabolism and disposition, 2018-09, Vol.46 (9), p.1285-1303

2018

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Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

The international journal of neuropsychopharmacology, 2008-12, Vol.11 (8), p.1123-1134

2008

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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control

Drug metabolism and disposition, 2017-10, Vol.45 (10), p.1049-1059

2017

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In vitro and physiologically‐based pharmacokinetic based assessment of drug–drug interaction potential of canagliflozin

British journal of clinical pharmacology, 2017-05, Vol.83 (5), p.1082-1096

2017

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Tethered spheroids as an in vitro hepatocyte model for drug safety screening

Biomaterials, 2012-03, Vol.33 (7), p.2165-2176

2012

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Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

Molecular pharmacology, 2016-05, Vol.89 (5), p.492-504

2016

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Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein

Glia, 2007-08, Vol.55 (11), p.1178-1188

2007

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Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia

The Journal of pharmacology and experimental therapeutics, 2004-06, Vol.309 (3), p.1221

2004

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Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Drug metabolism and disposition, 2014-08, Vol.42 (8), p.1301

2014

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Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model

Journal of applied toxicology, 2016-02, Vol.36 (2), p.320-329

2016

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MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity

Glia, 2007-10, Vol.55 (13), p.1362-1373

2007

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Recommendations for in vitro CYP3A4 mRNA data analysis for drug-drug interaction risk assessment from the IQ Induction working group

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S44-S44

2019

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Evaluation of the time-course of CYP Induction and impact on drug interaction risk assessment from the IQ Induction working group

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S40-S40

2019

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De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes

Current drug metabolism, 2012-09, Vol.13 (7), p.923

2012

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Considerations from the IQ induction working group in response to drug–drug interaction guidances from regulatory agencies

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S52-S52

2018

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Functional expression of the multidrug resistance protein 1 in microglia

The Journal of pharmacology and experimental therapeutics, 2003-10, Vol.307 (1), p.282

2003

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In vitro to in vivo extrapolation of intrinsic clearance for low turnover compounds using plated pooled donor human hepatocyte co-culture systems

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S52-S52

2019

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Therapeutic Protein Drug Interactions: A White Paper From the International Consortium for Innovation and Quality in Pharmaceutical Development

Clinical pharmacology and therapeutics, 2023-06, Vol.113 (6), p.1185-1198

2023

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Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations

Pharmacological reviews, 2001-12, Vol.53 (4), p.569

2001

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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment

Drug metabolism and disposition, 2021-01, Vol.49 (1), p.94-110

2021

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Gut-Restricted Selective Cyclooxygenase‑2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11570-11596

2021

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Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.689

2013

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Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

Brain (London, England : 1878), 2010-03, Vol.133 (3), p.808-821

2010

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The peroxidase activity of mitochondrial superoxide dismutase

Free radical biology & medicine, 2013-01, Vol.54, p.116-124

2013

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Multidrug resistance-associated proteins: expression and function in the central nervous system

Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control

In vitro and physiologically‐based pharmacokinetic based assessment of drug–drug interaction potential of canagliflozin

Tethered spheroids as an in vitro hepatocyte model for drug safety screening

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein

Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model

MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity

Recommendations for in vitro CYP3A4 mRNA data analysis for drug-drug interaction risk assessment from the IQ Induction working group

Evaluation of the time-course of CYP Induction and impact on drug interaction risk assessment from the IQ Induction working group

De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes

Considerations from the IQ induction working group in response to drug–drug interaction guidances from regulatory agencies

Functional expression of the multidrug resistance protein 1 in microglia

In vitro to in vivo extrapolation of intrinsic clearance for low turnover compounds using plated pooled donor human hepatocyte co-culture systems

Therapeutic Protein Drug Interactions: A White Paper From the International Consortium for Innovation and Quality in Pharmaceutical Development

Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations

Gut-Restricted Selective Cyclooxygenase‑2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer

Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes

Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

The peroxidase activity of mitochondrial superoxide dismutase

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