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Targeting the Raf kinases in human cancer: the Raf dimer dilemma

British journal of cancer, 2018-01, Vol.118 (1), p.3-8

2018

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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Nature communications, 2022-01, Vol.13 (1), p.486-486, Article 486

2022

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice

PloS one, 2012-09, Vol.7 (9), p.e45243-e45243

2012

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PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer

Pharmacology & therapeutics (Oxford), 2015-03, Vol.147, p.12-21

2015

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Molecular cell, 2016-12, Vol.64 (5), p.875-887

2016

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A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

Biochimica et biophysica acta. General subjects, 2020-06, Vol.1864 (6), p.129556-129556, Article 129556

2020

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Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway

Journal of molecular and cellular cardiology, 2012-12, Vol.53 (6), p.858-869

2012

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Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Molecular pharmacology, 2014-03, Vol.85 (3), p.408-419

2014

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Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1743-1754

2021

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Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (42), p.18202-18207

2010

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Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Journal of natural products (Washington, D.C.), 2022-06, Vol.85 (6), p.1603-1616

2022

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Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

Basic research in cardiology, 2015-05, Vol.110 (3), p.31-31, Article 31

2015

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Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

Molecular pharmacology, 2015-09, Vol.88 (3), p.512-523

2015

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Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction

Journal of natural products (Washington, D.C.), 2020-04, Vol.83 (4), p.1288-1294

2020

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Legal Harvesting, Sustainable Sourcing and Cascaded Use of Wood for Bioenergy: Their Coverage through Existing Certification Frameworks for Sustainable Forest Management

Forests, 2014-09, Vol.5 (9), p.2163-2211

2014

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Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

Oncogene, 2004-04, Vol.23 (20), p.3650-3658

2004

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Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3431-3435

2010

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Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression

The Journal of biological chemistry, 2014-02, Vol.289 (7), p.4145-4160

2014

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Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor

Investigational new drugs, 2012-08, Vol.30 (4), p.1379-1388

2012

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Design, synthesis and biological evaluation of novel stilbene-based antitumor agents

Bioorganic & medicinal chemistry, 2009-01, Vol.17 (2), p.512-522

2009

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STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in diabetic mice

Cardiovascular research, 2020-11, Vol.116 (13), p.2103-2115

2020

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Development of water soluble derivatives of cis-3, 4′, 5-trimethoxy-3′-aminostilbene for optimization and use in cancer therapy

Investigational new drugs, 2009-02, Vol.27 (1), p.41-52

2009

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Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect

The Journal of pharmacology and experimental therapeutics, 2010-09, Vol.334 (3), p.1023

2010

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Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

Oncotarget, 2016-01, Vol.7 (4), p.4399-4413

2016

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Targeting the Raf kinases in human cancer: the Raf dimer dilemma

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice

PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway

Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction

Legal Harvesting, Sustainable Sourcing and Cascaded Use of Wood for Bioenergy: Their Coverage through Existing Certification Frameworks for Sustainable Forest Management

Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression

Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor

Design, synthesis and biological evaluation of novel stilbene-based antitumor agents

STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in diabetic mice

Development of water soluble derivatives of cis-3, 4′, 5-trimethoxy-3′-aminostilbene for optimization and use in cancer therapy

Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

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