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Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

Current opinion in virology, 2021-08, Vol.49, p.36-40

2021

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Nucleosides for the treatment of respiratory RNA virus infections

Antiviral chemistry & chemotherapy, 2018-01, Vol.26, p.2040206618764483-2040206618764483

2018

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The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase

PloS one, 2013-07, Vol.8 (7), p.e68347

2013

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Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex

Molecules (Basel, Switzerland), 2022-05, Vol.27 (9), p.2918

2022

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Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

PLoS pathogens, 2018-02, Vol.14 (2), p.e1006889-e1006889

2018

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New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B

Antiviral research, 2011-05, Vol.90 (2), p.93-101

2011

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Advances in antiviral nucleoside analogues and their prodrugs

Antiviral chemistry & chemotherapy, 2018-01, Vol.26, p.2040206618781410-2040206618781410

2018

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Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

Antiviral research, 2020-10, Vol.182, p.104924-104924, Article 104924

2020

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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1862-1878

2015

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Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7504-7516

2015

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Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases

PLoS pathogens, 2021-12, Vol.17 (12), p.e1010151-e1010151

2021

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

PloS one, 2020-12, Vol.15 (12), p.e0240338

2020

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Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Antiviral research, 2017-07, Vol.143, p.151-161

2017

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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

International journal of molecular sciences, 2023-11, Vol.24 (22), p.16274

2023

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

British journal of pharmacology, 2014-07, Vol.171 (14), p.3364-3375

2014

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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004995-e1004995

2015

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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

PloS one, 2016-05, Vol.11 (5), p.e0154097-e0154097

2016

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Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.830-837

2012

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New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase

Antiviral research, 2016-10, Vol.134, p.63-76

2016

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Antimicrobial Strategies: Inhibition of Viral Polymerases by 3′-Hydroxyl Nucleosides

Drugs (New York, N.Y.), 2009-01, Vol.69 (2), p.151-166

Deval, Jerome

2009

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Meeting report: 34th international conference on antiviral research

Antiviral chemistry & chemotherapy, 2022, Vol.30, p.204020662211308-20402066221130853

2022

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Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

Antiviral research, 2018-07, Vol.155, p.76-88

2018

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Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.9488-9496

2008

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Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

Antimicrobial Agents and Chemotherapy, 2010-03, Vol.54 (3), p.977-983

2010

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Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

Nucleosides for the treatment of respiratory RNA virus infections

The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase

Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

Advances in antiviral nucleoside analogues and their prodrugs

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases

Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir

New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase

Antimicrobial Strategies: Inhibition of Viral Polymerases by 3′-Hydroxyl Nucleosides

Meeting report: 34th international conference on antiviral research

Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

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