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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients

PloS one, 2024-05, Vol.19 (5), p.e0304415

2024

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A Review of the Cardiovascular Safety of Prucalopride in Patients With Chronic Idiopathic Constipation

The American journal of gastroenterology, 2023-06, Vol.118 (6), p.955-960

2023

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Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Drugs in context, 2023, Vol.12

2023

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Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone

Skeletal muscle, 2018-10, Vol.8 (1), p.34-34, Article 34

2018

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Atrial ischemia promotes atrial fibrillation in dogs

Circulation (New York, N.Y.), 2003-04, Vol.107 (14), p.1930-1936

2003

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Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates

Molecular therapy. Methods & clinical development, 2023-06, Vol.29, p.286-302

2023

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Ranolazine: Ion‐channel‐blocking actions and in vivo electrophysiological effects

British journal of pharmacology, 2004-08, Vol.142 (8), p.1300-1308

2004

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Antiviral activity of maribavir in combination with other drugs active against human cytomegalovirus

Antiviral research, 2018-09, Vol.157, p.128-133

2018

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Disease pathology in the iduronate-2-sulfatase KO mouse: Opportunities for novel endpoints for second generation enzyme replacement strategies

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107227, Article 107227

2023

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Method for Simultaneous Epicardial and Endocardial Mapping of In Vivo Canine Heart: Application to Atrial Conduction Properties and Arrhythmia Mechanisms

Journal of cardiovascular electrophysiology, 2001-05, Vol.12 (5), p.548-555

2001

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Inhibitors of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)‑7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H‑spiro[chromeno[2,3‑b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9811-9831

2014

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Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6month period

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.84-91

2012

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Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9796-9810

2014

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Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.84-91

2012

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Pharmacological Prevention of Atrial Tachycardia Induced Atrial Remodeling as a Potential Therapeutic Strategy

Pacing and clinical electrophysiology, 2003-03, Vol.26 (3), p.752-764

2003

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The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF

Cardiovascular research, 2001-04, Vol.50 (1), p.75-84

2001

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Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718)

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9811-9831

2014

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1087-134 Improved calcium homeostasis and antiarrhythmic effects of a novel chimeric molecule that inhibits both type III phosphodiesterase and L-type calcium channel in failing hearts

Journal of the American College of Cardiology, 2004-03, Vol.43 (5), p.A189-A189

2004

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Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires étudiés chez le chien

Derakhchan, Katayoun

2002

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Analysis of atrial arrhythmias resulting from vagal tone: a model study

Annals of biomedical engineering, 2000-01, Vol.28 (SUPPL. 1), p.S-55

2000

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Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block : initiation in the conduction system followed by spatially unstable re-entry

Cardiovascular research, 1998-06, Vol.38 (3), p.617-630

1998

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Effects of Procainamide on Refractoriness, Conduction, and Excitable Gap in Canine Atrial Reentrant Tachycardia

Pacing and clinical electrophysiology, 1991-11, Vol.14 (11), p.1707-1713

1991

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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients

A Review of the Cardiovascular Safety of Prucalopride in Patients With Chronic Idiopathic Constipation

Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone

Atrial ischemia promotes atrial fibrillation in dogs

Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates

Ranolazine: Ion‐channel‐blocking actions and in vivo electrophysiological effects

Antiviral activity of maribavir in combination with other drugs active against human cytomegalovirus

Disease pathology in the iduronate-2-sulfatase KO mouse: Opportunities for novel endpoints for second generation enzyme replacement strategies

Method for Simultaneous Epicardial and Endocardial Mapping of In Vivo Canine Heart: Application to Atrial Conduction Properties and Arrhythmia Mechanisms

Inhibitors of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)‑7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H‑spiro[chromeno[2,3‑b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6month period

Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period

Pharmacological Prevention of Atrial Tachycardia Induced Atrial Remodeling as a Potential Therapeutic Strategy

The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF

Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718)

1087-134 Improved calcium homeostasis and antiarrhythmic effects of a novel chimeric molecule that inhibits both type III phosphodiesterase and L-type calcium channel in failing hearts

Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires étudiés chez le chien

Analysis of atrial arrhythmias resulting from vagal tone: a model study

Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block : initiation in the conduction system followed by spatially unstable re-entry

Effects of Procainamide on Refractoriness, Conduction, and Excitable Gap in Canine Atrial Reentrant Tachycardia

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