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A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

European journal of pharmaceutical sciences, 2014-10, Vol.63, p.167-177

2014

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Ex vivo whole liver perfusion model for prediction of drug-drug interactions and biliary excretion of rosuvastatin

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S48-S48

2019

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Human ex vivo model to study intestinal processes and microbiome induced metabolism

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S55-S56

2019

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Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

Clinical cancer research, 2013-02, Vol.19 (4), p.821-832

2013

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The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing

Current opinion in toxicology, 2021-09, Vol.27, p.8-17

2021

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The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

Toxicology in vitro, 2017-04, Vol.40, p.26-33

2017

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Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate

Drug metabolism and disposition, 2011-08, Vol.39 (8), p.1338-1344

2011

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The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip

International journal of molecular sciences, 2021-12, Vol.22 (24), p.13472

2021

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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Molecular pharmaceutics, 2017-09, Vol.14 (9), p.3142-3151

2017

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The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development

Pharmacological research, 2023-09, Vol.195, p.106853-106853, Article 106853

2023

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Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

The Journal of clinical investigation, 2010-08, Vol.120 (8), p.2942-2952

2010

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Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants

European journal of pharmaceutical sciences, 2018-11, Vol.124, p.217-227

2018

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Functions of OATP1A and 1B transporters in vivo: insights from mouse models

Trends in pharmacological sciences (Regular ed.), 2012-02, Vol.33 (2), p.100-108

2012

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Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling

European journal of pharmaceutical sciences, 2014-12, Vol.65, p.156-166

2014

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Intestine-on-a-chip: Next level in vitro research model of the human intestine

Current opinion in toxicology, 2021-03, Vol.25, p.6-14

2021

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Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel

International journal of cancer, 2015-01, Vol.136 (1), p.225-233

2015

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Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

Biomimetics (Basel, Switzerland), 2023-05, Vol.8 (2), p.226

2023

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Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

European journal of pharmaceutical sciences, 2018-03, Vol.115, p.175-184

2018

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Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1)

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.277-281

2009

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P172 - I-screen: An ex vivo human microbiome platform to study microbiome induced reverse metabolism of metabolites back to parent

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S75-S76

2020

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P82 - Pharmacokinetic application of normothermic perfused ex vivo porcine and diseased human livers

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S47-S47

2020

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High Impact of Oatp1a/1b Transporters on In Vivo Disposition of the Hydrophobic Anticancer Drug Paclitaxel

Clinical cancer research, 2011-01, Vol.17 (2), p.294-301

2011

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HEPATIC TRANSPORTER PROTEIN EXPRESSION IN FETUSES, NEONATES AND YOUNG INFANTS

Archives of disease in childhood, 2016-01, Vol.101 (1), p.e1.23-e1

2016

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A8 - Apical and basolateral flow rate influence intestinal absorption in fresh intestinal tissue inside a novel intestine on a chip model

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S20-S21

2020

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Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites

Molecular pharmacology, 2014-03, Vol.85 (3), p.520-530

2014

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A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

Ex vivo whole liver perfusion model for prediction of drug-drug interactions and biliary excretion of rosuvastatin

Human ex vivo model to study intestinal processes and microbiome induced metabolism

Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate

The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development

Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants

Functions of OATP1A and 1B transporters in vivo: insights from mouse models

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling

Intestine-on-a-chip: Next level in vitro research model of the human intestine

Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel

Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1)

P172 - I-screen: An ex vivo human microbiome platform to study microbiome induced reverse metabolism of metabolites back to parent

P82 - Pharmacokinetic application of normothermic perfused ex vivo porcine and diseased human livers

High Impact of Oatp1a/1b Transporters on In Vivo Disposition of the Hydrophobic Anticancer Drug Paclitaxel

HEPATIC TRANSPORTER PROTEIN EXPRESSION IN FETUSES, NEONATES AND YOUNG INFANTS

A8 - Apical and basolateral flow rate influence intestinal absorption in fresh intestinal tissue inside a novel intestine on a chip model

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites

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