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R-spondin protein family

Genome Biology, 2012-01, Vol.13 (3), p.242-242

2012

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A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

Nature communications, 2021-09, Vol.12 (1), p.5498-5498, Article 5498

2021

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WNT signaling in the normal intestine and colorectal cancer

Frontiers in bioscience, 2007-01, Vol.12, p.471

2007

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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Genes & development, 2014-02, Vol.28 (4), p.305-316

2014

Volltextzugriff (PDF)

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Cell reports (Cambridge), 2013-06, Vol.3 (6), p.1885-1892

2013

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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Nature (London), 2017-05, Vol.545 (7653), p.234-237

2017

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Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

Stem cells (Dayton, Ohio), 2012-11, Vol.30 (11), p.2378-2386

2012

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Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts”

Molecular and Cellular Biology, 2012-09, Vol.32 (18), p.3639-3647

2012

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Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

The Journal of biological chemistry, 2009-12, Vol.284 (51), p.35308-35313

2009

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Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling

PloS one, 2013-12, Vol.8 (12), p.e83110-e83110

2013

Volltextzugriff (PDF)

Method for estimating the single molecular affinity

Analytical biochemistry, 2012-02, Vol.421 (2), p.794-796

2012

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Lgr5 homologues associate with Wnt receptors and mediate R―spondin signalling

Nature (London), 2011-08, Vol.476 (7360), p.293-297

2011

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Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Blood, 2018-03, Vol.131 (9), p.982-994

2018

Volltextzugriff (PDF)

LEF1 turns over a new leaf

Nature genetics, 2001-05, Vol.28 (1), p.3-4

2001

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Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (2), p.376-381

2017

Volltextzugriff (PDF)

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

Cell, 2002-10, Vol.111 (2), p.241-250

2002

Volltextzugriff (PDF)

LEF1 turns over a new leaf

Nature genetics, 2001-05, Vol.28 (1), p.3-4

2001

Volltextzugriff (PDF)

Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

Clinical cancer research, 2016-08, Vol.22 (16_Supplement), p.PR05-PR05

2016

Volltextzugriff (PDF)

A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.e23174-e23174

2016

Volltextzugriff (PDF)

WNT Signaling and Lymphocyte Development

Cell, 2002-04, Vol.109 (2), p.S13-S19

2002

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Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.32-32

2017

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Surrogate Wnt agonists that phenocopy canonical Wnt and -catenin signalling

Nature (London), 2017-05, Vol.545 (7653), p.234

2017

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Abstract C21: Generation of Wnt- and mitogenic receptor binding bispecific antibodies to target cancer stem cells

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C21-C21

2015

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The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1

Oncogene, 1998-07, Vol.17 (4), p.503-510

1998

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R-spondin protein family

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

WNT signaling in the normal intestine and colorectal cancer

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts”

Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling

Method for estimating the single molecular affinity

Lgr5 homologues associate with Wnt receptors and mediate R―spondin signalling

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

LEF1 turns over a new leaf

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

LEF1 turns over a new leaf

Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

WNT Signaling and Lymphocyte Development

Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids

Surrogate Wnt agonists that phenocopy canonical Wnt and -catenin signalling

Abstract C21: Generation of Wnt- and mitogenic receptor binding bispecific antibodies to target cancer stem cells

The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1

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