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Implications of human genetic variation in CRISPR-based therapeutic genome editing

Nature medicine, 2017-09, Vol.23 (9), p.1095-1101

2017

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Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

Neuron (Cambridge, Mass.), 2013-08, Vol.79 (3), p.447-460

2013

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Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein

Molecular cell, 2018-04, Vol.70 (2), p.327-339.e5

2018

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Science (American Association for the Advancement of Science), 2014-01, Vol.343 (6166), p.84-87

2014

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α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

Current biology, 2014-10, Vol.24 (19), p.2319-2326

2014

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Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Cell, 2015-03, Vol.160 (6), p.1246-1260

2015

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Mechanistic Logic Underlying the Axonal Transport of Cytosolic Proteins

Neuron (Cambridge, Mass.), 2011-05, Vol.70 (3), p.441-454

2011

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Postoperative cognitive dysfunction is independent of type of surgery and anesthetic

Anesthesia and analgesia, 2011-05, Vol.112 (5), p.1179-1185

2011

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DNA targeting specificity of RNA-guided Cas9 nucleases

Nature biotechnology, 2013-09, Vol.31 (9), p.827-832

2013

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Prevalence of Dementia 7.5 Years after Coronary Artery Bypass Graft Surgery

Anesthesiology (Philadelphia), 2016-07, Vol.125 (1), p.62-71

2016

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Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

Cancer cell, 2015-03, Vol.27 (3), p.354-369

2015

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Optical control of mammalian endogenous transcription and epigenetic states

Nature (London), 2013-08, Vol.500 (7463), p.472-476

2013

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Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism

Cell reports (Cambridge), 2018-09, Vol.24 (12), p.3087-3098

2018

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CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

Scientific reports, 2015-06, Vol.5 (1), p.10833-10833, Article 10833

2015

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Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

Anesthesiology (Philadelphia), 2016-02, Vol.124 (2), p.353-361

2016

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Network meta-analysis on the log-hazard scale, combining count and hazard ratio statistics accounting for multi-arm trials: a tutorial

BMC medical research methodology, 2010-06, Vol.10 (1), p.54-54, Article 54

2010

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State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018

British journal of anaesthesia : BJA, 2019-10, Vol.123 (4), p.464-478

2019

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Conducting Indirect-Treatment-Comparison and Network-Meta-Analysis Studies: Report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: Part 2

Value in health, 2011-06, Vol.14 (4), p.429-437

2011

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Delineation of global, absolutely essential and conditionally essential pangenomes of Porphyromonas gingivalis

Scientific reports, 2024-09, Vol.14 (1), p.22247-12, Article 22247

2024

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Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness

Cancer discovery, 2021-07, Vol.11 (7), p.1808-1825

2021

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Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

Cell reports (Cambridge), 2015-07, Vol.12 (1), p.116-127

2015

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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C

Cell chemical biology, 2017-08, Vol.24 (8), p.1005-1016.e3

2017

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Translational reprogramming marks adaptation to asparagine restriction in cancer

Nature cell biology, 2019-12, Vol.21 (12), p.1590-1603

2019

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Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Nature communications, 2022-05, Vol.13 (1), p.2530-2530, Article 2530

2022

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Structure of the type V-C CRISPR-Cas effector enzyme

Molecular cell, 2022-05, Vol.82 (10), p.1865-1877.e4

2022

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Implications of human genetic variation in CRISPR-based therapeutic genome editing

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Mechanistic Logic Underlying the Axonal Transport of Cytosolic Proteins

Postoperative cognitive dysfunction is independent of type of surgery and anesthetic

DNA targeting specificity of RNA-guided Cas9 nucleases

Prevalence of Dementia 7.5 Years after Coronary Artery Bypass Graft Surgery

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

Optical control of mammalian endogenous transcription and epigenetic states

Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

Network meta-analysis on the log-hazard scale, combining count and hazard ratio statistics accounting for multi-arm trials: a tutorial

State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018

Conducting Indirect-Treatment-Comparison and Network-Meta-Analysis Studies: Report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: Part 2

Delineation of global, absolutely essential and conditionally essential pangenomes of Porphyromonas gingivalis

Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C

Translational reprogramming marks adaptation to asparagine restriction in cancer

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Structure of the type V-C CRISPR-Cas effector enzyme

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