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Discovery of highly potent, selective, covalent inhibitors of JAK3

Bioorganic & medicinal chemistry letters, 2017-10, Vol.27 (20), p.4622-4625

2017

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Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56lck inhibitor BMS-243117

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (13), p.2145-2149

2003

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Smart Beam Steering with a Slot-Loaded Miniaturized Patch Antenna

2022 IEEE International Conference on Signal Processing and Communications (SPCOM), 2022, p.1-4

2022

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Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2652-2657

2008

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5-Amino-pyrazoles as potent and selective p38α inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6886-6889

2010

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Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2587-2590

2003

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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

Biochemistry (Easton), 2004-08, Vol.43 (34), p.11056-11062

2004

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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3706-3712

2006

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Novel Tricyclic Inhibitors of IκB Kinase

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.1994-2005

2009

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Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy- N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (23), p.7006-7012

2011

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Novel methods for syntheses of substituted oxazoles by cyclization of vinyl bromides

Tetrahedron letters, 1992-12, Vol.33 (51), p.7835-7838

1992

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Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-4-amine derived inhibitors of IκB kinase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2646-2649

2009

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Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-ylmethyl acetamide (BMS-066)

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (23), p.7006-7012

2011

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5-Amino-pyrazoles as potent and selective p38a inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6886-6889

2010

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Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (13), p.2145-2149

2003

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Thrombin active site inhibitors

Bioorganic & Medicinal Chemistry, 1995-08, Vol.3 (8), p.999-1007

1995

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Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4007-4010

2003

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Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2411-2415

2006

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Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of I mu B kinase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2646-2649

2009

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Total synthesis of the complement inhibitor K-76 in racemic form. Structural assignment to "K-76 monocarboxylic acid"

Journal of the American Chemical Society, 1982-10, Vol.104 (20), p.5551-5553

1982

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Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6061-6066

2004

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Design and development of multiple antenna based system for RADAR applications

2015 IEEE MTT-S International Microwave and RF Conference (IMaRC), 2015, p.143-146

2015

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Implementation of HASPA algorithm for multiple antenna based RADAR signal processing

2016 International Conference on Microelectronics, Computing and Communications (MicroCom), 2016, p.1-4

2016

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Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Discovery of highly potent, selective, covalent inhibitors of JAK3

Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56lck inhibitor BMS-243117

Smart Beam Steering with a Slot-Loaded Miniaturized Patch Antenna

Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors

5-Amino-pyrazoles as potent and selective p38α inhibitors

Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors

Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Novel Tricyclic Inhibitors of IκB Kinase

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy- N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

Novel methods for syntheses of substituted oxazoles by cyclization of vinyl bromides

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-4-amine derived inhibitors of IκB kinase

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-ylmethyl acetamide (BMS-066)

5-Amino-pyrazoles as potent and selective p38a inhibitors

Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117

Thrombin active site inhibitors

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)

Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of I mu B kinase

Total synthesis of the complement inhibitor K-76 in racemic form. Structural assignment to "K-76 monocarboxylic acid"

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors

Design and development of multiple antenna based system for RADAR applications

Implementation of HASPA algorithm for multiple antenna based RADAR signal processing

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