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Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm

European journal of clinical pharmacology, 2017-10, Vol.73 (10), p.1219-1236

2017

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Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats

British journal of anaesthesia : BJA, 2005-06, Vol.94 (6), p.825-834

2005

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Buprenorphine induces ceiling in respiratory depression but not in analgesia

British journal of anaesthesia : BJA, 2006-05, Vol.96 (5), p.627-632

2006

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Trends in pharmacological sciences (Regular ed.), 2008-04, Vol.29 (4), p.186-191

2008

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Mechanism-based PK PD Modeling of the Respiratory Depressant Effect of Buprenorphine and Fentanyl in Healthy Volunteers

Clinical pharmacology and therapeutics, 2007-01, Vol.81 (1), p.50-58

2007

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Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

Pharmaceutical research, 2015-10, Vol.32 (10), p.3228-3237

2015

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Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice

Antimicrobial agents and chemotherapy, 2015-10, Vol.59 (10), p.6344-6351

2015

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Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

Pharmaceutical research, 2016-01, Vol.33 (1), p.40-51

2016

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Pharmacokinetic–pharmacodynamic modelling of drug‐induced QTc interval prolongation in man: prediction from in vitro human ether‐à‐go‐go‐related gene binding and functional inhibition assays and conscious dog studies

British journal of pharmacology, 2016-10, Vol.173 (19), p.2819-2832

2016

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Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

British journal of pharmacology, 2014-11, Vol.171 (22), p.5076-5092

2014

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Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers

Pharmaceutical research, 2005-09, Vol.22 (9), p.1432-1437

2005

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Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain

Pharmaceutical research, 2014-03, Vol.31 (3), p.593-606

2014

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Pharmacokinetic–pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors

Rheumatology (Oxford, England), 2005-07, Vol.44 (7), p.846-859

2005

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Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1136-1149

2005

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Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates

Journal of antimicrobial chemotherapy, 2014-05, Vol.69 (5), p.1330-1338

2014

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Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain

Clinical pharmacokinetics, 2002, Vol.41 (10), p.691-703

2002

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Response to letter to the editor from Dr. Mahmood: Original publication: “Predicting the ‘first dose in children’ of CYP3A-metabolized drugs: evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages”

Journal of clinical pharmacology, 2015-06, Vol.55 (6), p.721-721

2015

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Response to letter to the editor from Dr. Mahmood

Journal of clinical pharmacology, 2015-06, Vol.55 (6), p.721-721

2015

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Determination of factors required to increase uptake of influenza vaccination among hospital-based healthcare workers

The Journal of hospital infection, 2011-04, Vol.77 (4), p.327-331

2011

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A Model-Based Approach to Dose Selection in Early Pediatric Development

Clinical pharmacology and therapeutics, 2010-03, Vol.87 (3), p.294-302

2010

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Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD)

Pharmaceutical research, 2015-02, Vol.32 (2), p.617-627

2015

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Inter‐study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta‐analysis

British journal of pharmacology, 2015-09, Vol.172 (17), p.4364-4379

2015

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Naloxone reversal of buprenorphine-induced respiratory depression

Anesthesiology (Philadelphia), 2006-07, Vol.105 (1), p.51-57

2006

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PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

British journal of pharmacology, 2013-08, Vol.169 (7), p.1510-1524

2013

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Assessing the Probability of Drug‐Induced QTc‐Interval Prolongation During Clinical Drug Development

Clinical pharmacology and therapeutics, 2011-12, Vol.90 (6), p.867-875

2011

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Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm

Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats

Buprenorphine induces ceiling in respiratory depression but not in analgesia

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Mechanism-based PK PD Modeling of the Respiratory Depressant Effect of Buprenorphine and Fentanyl in Healthy Volunteers

Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

Pharmacokinetic–pharmacodynamic modelling of drug‐induced QTc interval prolongation in man: prediction from in vitro human ether‐à‐go‐go‐related gene binding and functional inhibition assays and conscious dog studies

Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers

Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain

Pharmacokinetic–pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors

Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics

Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain

Response to letter to the editor from Dr. Mahmood: Original publication: “Predicting the ‘first dose in children’ of CYP3A-metabolized drugs: evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages”

Response to letter to the editor from Dr. Mahmood

Determination of factors required to increase uptake of influenza vaccination among hospital-based healthcare workers

A Model-Based Approach to Dose Selection in Early Pediatric Development

Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD)

Inter‐study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta‐analysis

Naloxone reversal of buprenorphine-induced respiratory depression

PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

Assessing the Probability of Drug‐Induced QTc‐Interval Prolongation During Clinical Drug Development

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