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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1122-1135

2019

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Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1- a ]isoindole and Species Differences in Glucuronidation

Drug metabolism and disposition, 2023-07, Vol.51 (7), p.862-872

2023

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Biosynthetic Strategies for Macrocyclic Peptides

Molecules (Basel, Switzerland), 2021-06, Vol.26 (11), p.3338

2021

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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Molecular pharmaceutics, 2020-11, Vol.17 (11), p.4114-4124

2020

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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates

Molecular cancer therapeutics, 2018-03, Vol.17 (3), p.677-685

2018

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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

Drug metabolism and disposition, 2020-07, Vol.48 (7), p.528-536

2020

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Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Current drug metabolism, 2012-09, Vol.13 (7), p.901-910

2012

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Drug–Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug–Drug Interaction Prediction

Pharmaceutical research, 2012-07, Vol.29 (7), p.1960-1976

2012

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Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1156-1163

2019

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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1146-1155

2019

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A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834

Drug metabolism and disposition, 2015-06, Vol.43 (6), p.908-915

2015

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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9603-9622

2020

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An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes

Journal of pharmacological and toxicological methods, 2012-11, Vol.66 (3), p.270-275

2012

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Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY ® ) Antibody-Drug Conjugate in Sprague Dawley Rats

Journal of clinical medicine, 2021-03, Vol.10 (6), p.1323

2021

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.5014-5021

2013

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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1840-1849

2011

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Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

Communications medicine, 2024-05, Vol.4 (1), p.87-87, Article 87

2024

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Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

International journal of molecular sciences, 2017-07, Vol.18 (7), p.1553

2017

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Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats

Chemical research in toxicology, 2010-11, Vol.23 (11), p.1824-1832

2010

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Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8691-8705

2017

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Discovery of Unprecedented Human Stercobilin Conjugates

Drug metabolism and disposition, 2024-09, Vol.52 (9), p.981-987

2024

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A decades-long investigation of acute metabolism-based hepatotoxicity by herbal constituents: a case study of pennyroyal oil

Drug metabolism reviews, 2015-02, Vol.47 (1), p.12-20

2015

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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species

Drug metabolism and disposition, 2022-03, Vol.50 (3), p.197-203

2022

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Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Chemical research in toxicology, 2002-03, Vol.15 (3), p.269-299

2002

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Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs

Journal of medicinal chemistry, 2021-06, Vol.64 (11), p.7045-7059

2021

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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1- a ]isoindole and Species Differences in Glucuronidation

Biosynthetic Strategies for Macrocyclic Peptides

Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates

Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Drug–Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug–Drug Interaction Prediction

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates

Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834

Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates

An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes

Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY ® ) Antibody-Drug Conjugate in Sprague Dawley Rats

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats

Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)

Discovery of Unprecedented Human Stercobilin Conjugates

A decades-long investigation of acute metabolism-based hepatotoxicity by herbal constituents: a case study of pennyroyal oil

Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species

Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs

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