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Weaponisation ‘on the fly’: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies

Insect biochemistry and molecular biology, 2020-03, Vol.118, p.103310-103310, Article 103310

2020

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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

The Journal of biological chemistry, 2024-04, Vol.300 (4), p.107155-107155, Article 107155

2024

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Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (34), p.E8077-E8085

2018

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The hEag1 K+ Channel Inhibitor Astemizole Stimulates Ca2+ Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10533

2022

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A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5

Frontiers in pharmacology, 2021-01, Vol.11, p.563858-563858

2021

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Functional Voltage-Gated Sodium Channels Are Present in the Human B Cell Membrane

Cells (Basel, Switzerland), 2022-04, Vol.11 (7), p.1225

2022

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Characterization of a Novel High-Selectivity Kv1.3 Inhibitor Peptide

Biophysical journal, 2020-02, Vol.118 (3), p.263a-263a

2020

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Immunomagnetic cell separation is a suitable method for T cell electrophysiology and ion channel pharmacology

The Journal of immunology (1950), 2019-05, Vol.202 (1_Supplement), p.131-131.9

2019

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Lipopolysaccharide influences the plasma and brain pharmacokinetics of subcutaneously-administered HsTX1[R14A], a KV1.3-blocking peptide

Toxicon (Oxford), 2021-05, Vol.195, p.29-36

2021

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A Biodistribution Study of the Radiolabeled Kv1.3-Blocking Peptide DOTA-HsTX1[R14A] Demonstrates Brain Uptake in a Mouse Model of Neuroinflammation

Molecular pharmaceutics, 2023-01, Vol.20 (1), p.255-266

2023

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity

Biochemical pharmacology, 2022-05, Vol.199, p.115023-115023, Article 115023

2022

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A disulfide-stabilised helical hairpin fold in acrorhagin I: An emerging structural motif in peptide toxins

Journal of structural biology, 2021-06, Vol.213 (2), p.107692, Article 107692

2021

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Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

Toxicon (Oxford), 2018-08, Vol.150, p.50-59

2018

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A Novel Spider Peptide that Affects the Voltage Gated Potassium Channel Kv1.5

Biophysical journal, 2021-02, Vol.120 (3), p.246a-247a

2021

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Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells

Channels (Austin, Tex.), 2021-01, Vol.15 (1), p.53-66

2021

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Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

Biochemical pharmacology, 2020-04, Vol.174, p.113782, Article 113782

2020

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Selective Na^sub V^1.1 activation rescues Dravet syndrome mice from seizures and premature death

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (34), p.E8077

2018

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Lipopolysaccharide influences the plasma and brain pharmacokinetics of subcutaneously-administered HsTX1[R14A], a K V 1.3-blocking peptide

Toxicon (Oxford), 2021-05, Vol.195, p.29

2021

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Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (34), p.E8077

2018

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Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells

Channels, 2021, Vol.15 (1), p.53-66

2021

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Weaponisation ‘on the fly’: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies

KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

The hEag1 K+ Channel Inhibitor Astemizole Stimulates Ca2+ Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5

Functional Voltage-Gated Sodium Channels Are Present in the Human B Cell Membrane

Characterization of a Novel High-Selectivity Kv1.3 Inhibitor Peptide

Immunomagnetic cell separation is a suitable method for T cell electrophysiology and ion channel pharmacology

Lipopolysaccharide influences the plasma and brain pharmacokinetics of subcutaneously-administered HsTX1[R14A], a KV1.3-blocking peptide

A Biodistribution Study of the Radiolabeled Kv1.3-Blocking Peptide DOTA-HsTX1[R14A] Demonstrates Brain Uptake in a Mouse Model of Neuroinflammation

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3

sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity

A disulfide-stabilised helical hairpin fold in acrorhagin I: An emerging structural motif in peptide toxins

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

A Novel Spider Peptide that Affects the Voltage Gated Potassium Channel Kv1.5

Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

Selective Na^sub V^1.1 activation rescues Dravet syndrome mice from seizures and premature death

Lipopolysaccharide influences the plasma and brain pharmacokinetics of subcutaneously-administered HsTX1[R14A], a K V 1.3-blocking peptide

Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death

Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells

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