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Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab

Molecular pharmaceutics, 2016-09, Vol.13 (9), p.2996-3003

2016

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Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics

Analytical chemistry (Washington), 2023-12, Vol.95 (49), p.17957-17961

2023

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Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins

Toxicologic pathology, 2021-04, Vol.49 (3), p.634-646

2021

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Hyaluronic Acid–Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics

Bioconjugate chemistry, 2019-11, Vol.30 (11), p.2782-2789

2019

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Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling

Toxicology and applied pharmacology, 2022-03, Vol.438 (N/A), p.115830-115830, Article 115830

2022

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In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes

Toxicology letters, 2017-03, Vol.269, p.23-32

2017

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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

Frontiers in pharmacology, 2021-05, Vol.12, p.601569-601569

2021

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Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

PloS one, 2019-06, Vol.14 (6), p.e0218613

2019

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Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits

Toxicologic pathology, 2021-04, Vol.49 (3), p.647-655

2021

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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology

Molecular pharmaceutics, 2022-05, Vol.19 (5), p.1540-1547

2022

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Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

Translational vision science & technology, 2019-11, Vol.8 (6), p.1

2019

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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

Alzheimer's research & therapy, 2019-12, Vol.11 (1), p.97-97, Article 97

2019

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Estimate of the mutation rate per nucleotide in humans

Genetics (Austin), 2000-09, Vol.156 (1), p.297-304

2000

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Translational Research to Develop a Human PBPK Models Tool Kit-Volatile Organic Compounds (VOCs)

Journal of Toxicology and Environmental Health, Part A, 2012-01, Vol.75 (1), p.6-24

2012

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Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

mAbs, 2016-08, Vol.8 (6), p.1098-1106

2016

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Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Toxicology and applied pharmacology, 2011-12, Vol.257 (3), p.365-376

2011

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Targeted IgMs agonize ocular targets with extended vitreal exposure

mAbs, 2020-01, Vol.12 (1), p.1818436

2020

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DNA Variability and Recombination Rates at X-Linked Loci in Humans

Genetics (Austin), 1998-11, Vol.150 (3), p.1133-1141

1998

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Development and application of a physiologically based pharmacokinetic model for triadimefon and its metabolite triadimenol in rats and humans

Toxicology letters, 2011-08, Vol.205 (2), p.154-162

2011

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Contrasting Evolutionary Histories of Two Introns of the Duchenne Muscular Dystrophy Gene, Dmd, in Humans

Genetics (Austin), 2000-08, Vol.155 (4), p.1855-1864

2000

Volltextzugriff (PDF)

Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy

Toxicologic pathology, 2021-04, Vol.49 (3), p.610-620

2021

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Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid

Clinical pharmacology and therapeutics, 2022-04, Vol.111 (4), p.826-834

2022

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In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes

Toxicology letters, 2017-03, Vol.269 (C)

2017

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A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites

Chemico-biological interactions, 2015-08, Vol.238 (C), p.102-110

2015

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Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling

Inhalation toxicology, 2016-09, Vol.28 (11), p.520-535

2016

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Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab

Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics

Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins

Hyaluronic Acid–Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics

Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling

In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits

Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

Estimate of the mutation rate per nucleotide in humans

Translational Research to Develop a Human PBPK Models Tool Kit-Volatile Organic Compounds (VOCs)

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Targeted IgMs agonize ocular targets with extended vitreal exposure

DNA Variability and Recombination Rates at X-Linked Loci in Humans

Development and application of a physiologically based pharmacokinetic model for triadimefon and its metabolite triadimenol in rats and humans

Contrasting Evolutionary Histories of Two Introns of the Duchenne Muscular Dystrophy Gene, Dmd, in Humans

Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy

Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid

In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes

A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites

Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling

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