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Network analyses reveal pervasive functional regulation between proteases in the human protease web

PLoS biology, 2014-05, Vol.12 (5), p.e1001869-e1001869

2014

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Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Nature communications, 2022-10, Vol.13 (1), p.6497-6497, Article 6497

2022

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Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

Blood, 2008-10, Vol.112 (8), p.3455-3464

2008

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Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function

PloS one, 2013-12, Vol.8 (12), p.e82944-e82944

2013

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LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

PloS one, 2007-03, Vol.2 (3), p.e312-e312

2007

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Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding

The Journal of biological chemistry, 2008-07, Vol.283 (28), p.19389-19399

2008

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Proteolytic Processing of SDF-1α Reveals a Change in Receptor Specificity Mediating HIV-Associated Neurodegeneration

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (50), p.19182-19187

2006

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IL-27 promotes T cell-dependent colitis through multiple mechanisms

The Journal of experimental medicine, 2011-01, Vol.208 (1), p.115-123

2011

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IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

The Journal of experimental medicine, 2010-12, Vol.207 (13), p.2895-2906

2010

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Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Data in brief, 2016-06, Vol.7, p.299-310

2016

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Novel pyridone EP4 agonists featuring allylic alcohol ω-chains

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (10), p.127104-127104, Article 127104

2020

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Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

Arthritis and rheumatism, 2010-12, Vol.62 (12), p.3645-3655

2010

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Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria

ACS medicinal chemistry letters, 2021-07, Vol.12 (7), p.1116-1123

2021

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Tu1672 IL-21 Production and Function in Peripheral Immune Cells From Crohn's Disease Patients

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-819-S-819

2013

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CTLs Target Th Cells That Acquire Bystander MHC Class I-Peptide Complex from APCs

Journal of Immunology, 2007-07, Vol.179 (2), p.830-836

2007

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PS1-20 IL-27 promotes T-cell dependent colitis through restriction of regulatory T-cell differentiation

Cytokine (Philadelphia, Pa.), 2010-10, Vol.52 (1-2), p.21-21

2010

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Unsupervised Characterization of the NURTuRE Cohort Reveals Gene Expression and Tissue Remodeling Dynamics Along a Synthetic CKD Progression Axis: SA-PO1011

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.883-883

2022

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A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

Immunity (Cambridge, Mass.), 2001, Vol.14 (5), p.591-602

2001

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Precision Medicine Approach Identifies Patients with IgA Nephropathy at Risk for Progression Using Endothelin Activation Signatures: PO1593

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.499-499

2021

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Preclinical Efficacy of CHK-336: A First in Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxalurias: FR-PO334

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.415-415

2022

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A Multi-Omics Approach to IgA Nephropathy Characterization in the NURTuRE Cohort Enables Precision-Based Treatment Approaches: FR-OR60

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.34-34

2022

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Single Nuclei RNA-Seq Reveals Cell-Type Specific Responses to Disease and Enalapril in the gddY Mouse Model of IgA Nephropathy: TH-PO419

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.163-163

2022

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Discovery of CHK-336: A First-in-Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxaluria: PO1620

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.514-514

2020

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Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8

FEBS letters, 2008-03, Vol.582 (5), p.819-825

2008

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Network analyses reveal pervasive functional regulation between proteases in the human protease web

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding

Proteolytic Processing of SDF-1α Reveals a Change in Receptor Specificity Mediating HIV-Associated Neurodegeneration

IL-27 promotes T cell-dependent colitis through multiple mechanisms

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Novel pyridone EP4 agonists featuring allylic alcohol ω-chains

Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria

Tu1672 IL-21 Production and Function in Peripheral Immune Cells From Crohn's Disease Patients

CTLs Target Th Cells That Acquire Bystander MHC Class I-Peptide Complex from APCs

PS1-20 IL-27 promotes T-cell dependent colitis through restriction of regulatory T-cell differentiation

Unsupervised Characterization of the NURTuRE Cohort Reveals Gene Expression and Tissue Remodeling Dynamics Along a Synthetic CKD Progression Axis: SA-PO1011

A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

Precision Medicine Approach Identifies Patients with IgA Nephropathy at Risk for Progression Using Endothelin Activation Signatures: PO1593

Preclinical Efficacy of CHK-336: A First in Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxalurias: FR-PO334

A Multi-Omics Approach to IgA Nephropathy Characterization in the NURTuRE Cohort Enables Precision-Based Treatment Approaches: FR-OR60

Single Nuclei RNA-Seq Reveals Cell-Type Specific Responses to Disease and Enalapril in the gddY Mouse Model of IgA Nephropathy: TH-PO419

Discovery of CHK-336: A First-in-Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxaluria: PO1620

Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8

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