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Cyp1 Inhibition Prevents Doxorubicin‐Induced Cardiomyopathy in a Zebrafish Heart‐Failure Model

Chembiochem : a European journal of chemical biology, 2020-07, Vol.21 (13), p.1905-1910

2020

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Comparison of the Rat and Human Dorsal Root Ganglion Proteome

Scientific reports, 2018-09, Vol.8 (1), p.13469-10, Article 13469

2018

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A mass spectrometry-based proteome map of drug action in lung cancer cell lines

Nature chemical biology, 2020-10, Vol.16 (10), p.1111-1119

2020

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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines

Nature chemical biology, 2020-10, Vol.16 (10), p.1149-1149

2020

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Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6739-6744

2011

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Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

Blood, 2011-05, Vol.117 (21), p.5683-5691

2011

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Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2

ChemMedChem, 2017-06, Vol.12 (12), p.917-924

2017

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Monovalent protein-degraders – Insights and future perspectives

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (12), p.127202-127202, Article 127202

2020

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Cover Picture: Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2 (ChemMedChem 12/2017)

ChemMedChem, 2017-06, Vol.12 (12), p.860-860

2017

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Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts

Journal of medicinal chemistry, 2018-03, Vol.61 (5), p.1767-1773

2018

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Abstract 298: Dissection of drug-protein interactions by HR-LiP-MS in target validation and lead optimization

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.298-298

2021

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Abstract 4006: High-Resolution Limited Proteolysis (HR-LIP), a novel approach for target validation and lead compound optimization

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4006-4006

2020

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Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts: Miniperspective

Journal of medicinal chemistry, 2018-03, Vol.61 (5), p.1767-1773

2018

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Chemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins

Cell chemical biology, 2022-11, Vol.29 (11), p.1639-1648.e4

2022

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Nature cell biology, 2014-11, Vol.16 (11), p.1069-1079

2014

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Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay

ACS medicinal chemistry letters, 2021-08, Vol.12 (8), p.1288-1294

2021

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Natural products reveal cancer cell dependence on oxysterol-binding proteins

Nature chemical biology, 2011-08, Vol.7 (9), p.639-647

2011

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Abstract 2024: High resolution limited proteolysis (HR-LiP), a novel structural proteomics approach for the prediction of small molecule-protein binding events

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2024-2024

2023

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Abstract 2136: Prediction of small molecule-protein binding events for BRD4 and EGFR inhibitors using HR-LiP, a novel structural proteomics approach

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2136-2136

2022

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Affinity‐Based Chemoproteomics for Target Identification

Target Discovery and Validation, 2020

Plowright, Alleyn T

2020

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Cyp1 Inhibition Prevents Doxorubicin‐Induced Cardiomyopathy in a Zebrafish Heart‐Failure Model

Chembiochem : a European journal of chemical biology, 2020-07, Vol.21 (13), p.1780-1780

2020

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Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

ACS medicinal chemistry letters, 2016-01, Vol.7 (1), p.72-76

2016

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Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

ACS chemical biology, 2016-01, Vol.11 (1), p.121-131

2016

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Cyp1 Inhibition Prevents Doxorubicin‐Induced Cardiomyopathy in a Zebrafish Heart‐Failure Model

Comparison of the Rat and Human Dorsal Root Ganglion Proteome

A mass spectrometry-based proteome map of drug action in lung cancer cell lines

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers

Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2

Monovalent protein-degraders – Insights and future perspectives

Cover Picture: Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2 (ChemMedChem 12/2017)

Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts

Abstract 298: Dissection of drug-protein interactions by HR-LiP-MS in target validation and lead optimization

Abstract 4006: High-Resolution Limited Proteolysis (HR-LIP), a novel approach for target validation and lead compound optimization

Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts: Miniperspective

Chemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Rapid Evaluation of Small Molecule Cellular Target Engagement with a Luminescent Thermal Shift Assay

Natural products reveal cancer cell dependence on oxysterol-binding proteins

Abstract 2024: High resolution limited proteolysis (HR-LiP), a novel structural proteomics approach for the prediction of small molecule-protein binding events

Abstract 2136: Prediction of small molecule-protein binding events for BRD4 and EGFR inhibitors using HR-LiP, a novel structural proteomics approach

Affinity‐Based Chemoproteomics for Target Identification

Cyp1 Inhibition Prevents Doxorubicin‐Induced Cardiomyopathy in a Zebrafish Heart‐Failure Model

A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV‑1 Infected Cells

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

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