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Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

Journal of the American Chemical Society, 2020-02, Vol.142 (6), p.3094-3103

2020

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Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

Journal of organic chemistry, 2021-01, Vol.86 (2), p.1730-1747

2021

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Synthesis of 1‑(tert-Butyl) 4‑Methyl (1R,2S,4R)‑2-Methylcyclohexane-1,4-dicarboxylate from Hagemann’s tert-Butyl Ester for an Improved Synthesis of BMS-986251

Journal of organic chemistry, 2020-08, Vol.85 (16), p.10988-10993

2020

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Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3224-3229

2008

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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1221-1227

2020

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Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.855-861

2017

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Discovery of N-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists

Journal of medicinal chemistry, 2002-08, Vol.45 (18), p.3829-3835

2002

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Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1093-1096

2003

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Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (15), p.3937-3942

2006

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Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry

Journal of organic chemistry, 1997-01, Vol.62 (1), p.201-203

1997

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Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4880-4884

1995

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Synthesis of 2-acetylbicyclo[2.2.1]hept-2-ene

Journal of organic chemistry, 1993-05, Vol.58 (11), p.3188-3190

1993

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Synthesis of 2-acetylbicyclo[2.2.1]hept-2-ene. [Erratum to document cited in CA119(3):27738j]

Journal of organic chemistry, 1993-08, Vol.58 (17), p.4774-4774

1993

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A Convenient Synthesis of Mono- and Polyhalogenated Benzocyclanones

Synthetic communications, 1994-10, Vol.24 (19), p.2777-2788

1994

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ChemInform Abstract: Direct Displacement of -OH by Nucleophiles in Hydroxymethylimidazoles

ChemInform, 2000-07, Vol.31 (30), p.no-no

2000

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ChemInform Abstract: Studies Towards Understanding the Mechanism of the Unusual Rearrangement of Certain 5-Propargyloxyindoles

ChemInform, 2000-08, Vol.31 (35), p.no-no

2000

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Heteroarylsulfonamido Biphenyls as Potent Dual Antagonists Blocking Angiotensin and Endothelin Receptors and Useful as Novel Anti-hypertensives

19th International Congress of Heterocyclic Chemistry, 2003, p.69-69

2003

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Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines

Organic & biomolecular chemistry, 2022-12, Vol.2 (48), p.9746-9752

2022

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Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines

Organic & biomolecular chemistry, 2022-12, Vol.20 (48), p.9746-9752

2022

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Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers

Experimental cell research, 2015-03, Vol.332 (2), p.267-277

2015

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

Journal of medicinal chemistry, 2019-11, Vol.62 (21), p.9931-9946

2019

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A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist

Journal of organic chemistry, 2021-07, Vol.86 (13), p.8851-8861

2021

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Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Synthesis of 1‑(tert-Butyl) 4‑Methyl (1R,2S,4R)‑2-Methylcyclohexane-1,4-dicarboxylate from Hagemann’s tert-Butyl Ester for an Improved Synthesis of BMS-986251

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

Discovery of N-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists

Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry

Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

Synthesis of 2-acetylbicyclo[2.2.1]hept-2-ene

Synthesis of 2-acetylbicyclo[2.2.1]hept-2-ene. [Erratum to document cited in CA119(3):27738j]

Discovery of N-(2-chloro-6-methylphenyl)-2-6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyr imidin-4-ylaminothiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays

A Convenient Synthesis of Mono- and Polyhalogenated Benzocyclanones

ChemInform Abstract: Direct Displacement of -OH by Nucleophiles in Hydroxymethylimidazoles

ChemInform Abstract: Studies Towards Understanding the Mechanism of the Unusual Rearrangement of Certain 5-Propargyloxyindoles

Heteroarylsulfonamido Biphenyls as Potent Dual Antagonists Blocking Angiotensin and Endothelin Receptors and Useful as Novel Anti-hypertensives

Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines

Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines

Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist

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