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Foliglurax, a positive allosteric modulator of the metabotrophic glutamate receptor 4, protects dopaminergic neurons in MPTP-lesioned male mice

Brain research, 2023-06, Vol.1809, p.148349, Article 148349

2023

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Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8515-8537

2017

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An mGlu4‐Positive Allosteric Modulator Alleviates Parkinsonism in Primates

Movement disorders, 2018-10, Vol.33 (10), p.1619-1631

2018

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Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

The Journal of neuroscience, 2008-10, Vol.28 (44), p.11263-11268

2008

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Nature neuroscience, 2001-09, Vol.4 (9), p.873-874

2001

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Guidepost neurons for the lateral olfactory tract: Expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons

Developmental neurobiology (Hoboken, N.J.), 2012-12, Vol.72 (12), p.1559-1576

2012

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Regulation of Main Olfactory Bulb Mitral Cell Excitability by Metabotropic Glutamate Receptor mGluR1

Journal of neurophysiology, 2004-11, Vol.92 (5), p.3085-3096

2004

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Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition

The Journal of physiology, 2004-02, Vol.555 (1), p.125-135

2004

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Staggerer Phenotype in Retinoid-Related Orphan Receptor α -Deficient Mice

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3960-3965

1998

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Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

Molecular and Cellular Biology, 1999-10, Vol.19 (10), p.6488-6499

1999

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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

Nature (London), 1994-11, Vol.372 (6503), p.237-243

1994

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Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections

The Journal of neuroscience, 2003-07, Vol.23 (13), p.5634-5644

2003

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Immunolocalization of the mGluR1b Splice Variant of the Metabotropic Glutamate Receptor 1 at Parallel Fiber‐Purkinje Cell Synapses in the Rat Cerebellar Cortex

Journal of neurochemistry, 2000-03, Vol.74 (3), p.1301-1309

2000

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Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells

The Journal of physiology, 2002-05, Vol.541 (1), p.113-121

2002

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An m G lu4‐ P ositive A llosteric M odulator A lleviates P arkinsonism in P rimates

Movement disorders, 2018-10, Vol.33 (10), p.1619-1631

2018

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A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

The Journal of experimental medicine, 2000-05, Vol.191 (10), p.1755-1764

2000

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Regulation of synaptic plasticity by mGluR1 studied in vivo in mGluR1 mutant mice

Brain research, 1997-06, Vol.761 (1), p.121-126

1997

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The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors

Neuropharmacology, 2005, Vol.49 Suppl 1, p.13-25

2005

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The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior

The EMBO journal, 1997-11, Vol.16 (22), p.6762-6771

1997

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Inhibited Gastrulation in Mouse Embryos Overexpressing the Leukemia Inhibitory Factor

Proceedings of the National Academy of Sciences - PNAS, 1992-09, Vol.89 (17), p.8195-8199

1992

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Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

The EMBO journal, 1998-07, Vol.17 (14), p.3867-3877

1998

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Up-Regulation of P2X 4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

The Journal of neuroscience, 2008-10, Vol.28 (44), p.11263-11268

2008

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Impaired preprodynorphin, but not preproenkephalin, mRNA induction in the striatum of mGluR1 mutant mice in response to acute administration of the full dopamine D1 agonist SKF-82958

Synapse (New York, N.Y.), 2002-05, Vol.44 (2), p.86-93

2002

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Activation of Metabotropic Glutamate Receptor Subtype 1/Protein Kinase C/Mitogen-Activated Protein Kinase Pathway Is Required for Postischemic Long-Term Potentiation in the Striatum

Molecular pharmacology, 2001-10, Vol.60 (4), p.808-815

2001

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Impaired preprodynorphin, but not preproenkephalin, mRNA induction in the striatum of mGluR1 mutant mice in response to acute administration of the full dopamine D 1 agonist SKF‐82958

Synapse (New York, N.Y.), 2002-05, Vol.44 (2), p.86-93

2002

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Foliglurax, a positive allosteric modulator of the metabotrophic glutamate receptor 4, protects dopaminergic neurons in MPTP-lesioned male mice

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

An mGlu4‐Positive Allosteric Modulator Alleviates Parkinsonism in Primates

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Guidepost neurons for the lateral olfactory tract: Expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons

Regulation of Main Olfactory Bulb Mitral Cell Excitability by Metabotropic Glutamate Receptor mGluR1

Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition

Staggerer Phenotype in Retinoid-Related Orphan Receptor α -Deficient Mice

Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections

Immunolocalization of the mGluR1b Splice Variant of the Metabotropic Glutamate Receptor 1 at Parallel Fiber‐Purkinje Cell Synapses in the Rat Cerebellar Cortex

Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells

An m G lu4‐ P ositive A llosteric M odulator A lleviates P arkinsonism in P rimates

A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

Regulation of synaptic plasticity by mGluR1 studied in vivo in mGluR1 mutant mice

The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors

The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior

Inhibited Gastrulation in Mouse Embryos Overexpressing the Leukemia Inhibitory Factor

Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

Up-Regulation of P2X 4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Impaired preprodynorphin, but not preproenkephalin, mRNA induction in the striatum of mGluR1 mutant mice in response to acute administration of the full dopamine D1 agonist SKF-82958

Activation of Metabotropic Glutamate Receptor Subtype 1/Protein Kinase C/Mitogen-Activated Protein Kinase Pathway Is Required for Postischemic Long-Term Potentiation in the Striatum

Impaired preprodynorphin, but not preproenkephalin, mRNA induction in the striatum of mGluR1 mutant mice in response to acute administration of the full dopamine D 1 agonist SKF‐82958

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