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ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors

Bioorganic & medicinal chemistry letters, 2021-02, Vol.33, p.127721-127721, Article 127721

2021

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Cell-free formation of protease-resistant prion protein

Nature (London), 1994-08, Vol.370 (6489), p.471-474

1994

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ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (15), p.2622-2626

2018

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Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2250-2253

2007

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Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors

ACS medicinal chemistry letters, 2021-01, Vol.12 (1), p.129-135

2021

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4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5191-5194

2009

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Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.44-48

2008

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A Kinetic Model for Amyloid Formation in the Prion Diseases: Importance of Seeding

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.5959-5963

1993

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Predisposition of prion protein homozygotes to Creutzfeldt-Jakob disease can be explained by a nucleation-dependent polymerization mechanism

Journal of the American Chemical Society, 1994-05, Vol.116 (9), p.4109-4110

1994

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Convenient synthesis of N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides

Tetrahedron letters, 2006-11, Vol.47 (46), p.8079-8081

2006

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Synthesis of eight-membered carbocycles via intramolecular [6.pi. + 2.pi.] photocycloaddition of alkenyl tropones

Journal of the American Chemical Society, 1986-03, Vol.108 (6), p.1327-1328

1986

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Mechanistic and preparative studies of the intramolecular photocyclization of methylated 2-(4-pentenyl)tropones

Journal of organic chemistry, 1989-02, Vol.54 (3), p.592-601

1989

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Models for protein assembly in the prion diseases

Come, Jon H

1994

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Convenient Synthesis of N-(4-(2-Aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides

ChemInform, 2007-02, Vol.38 (8), p.no-no

2007

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Synthesis of eight-membered carbocycles via intramolecular [6π+2π] photocycloaddition of alkenyltropones

Journal of the American Chemical Society, 1986, Vol.108 (6), p.1327-1328

1986

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Novel Thiol-Based TACE Inhibitors: Rational Design, Synthesis, and SAR of Thiol-Containing Aryl Sulfonamides

ChemInform, 2007-08, Vol.38 (35), p.no-no

2007

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Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3561-3578

1994

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Guanosine Derivatives as Immunostimulants. Discovery of Loxoribine

Nucleosides & nucleotides, 1994-03, Vol.13 (1-3), p.551-562

1994

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ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors

Cell-free formation of protease-resistant prion protein

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors

Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)

Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors

4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitors

Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones

A Kinetic Model for Amyloid Formation in the Prion Diseases: Importance of Seeding

Predisposition of prion protein homozygotes to Creutzfeldt-Jakob disease can be explained by a nucleation-dependent polymerization mechanism

Convenient synthesis of N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides

Synthesis of eight-membered carbocycles via intramolecular [6.pi. + 2.pi.] photocycloaddition of alkenyl tropones

Mechanistic and preparative studies of the intramolecular photocyclization of methylated 2-(4-pentenyl)tropones

Models for protein assembly in the prion diseases

Convenient Synthesis of N-(4-(2-Aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides

Synthesis of eight-membered carbocycles via intramolecular [6π+2π] photocycloaddition of alkenyltropones

Novel Thiol-Based TACE Inhibitors: Rational Design, Synthesis, and SAR of Thiol-Containing Aryl Sulfonamides

Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds

Guanosine Derivatives as Immunostimulants. Discovery of Loxoribine

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