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α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (33), p.13404-13409

2012

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Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

Neurochemical research, 2020-07, Vol.45 (7), p.1551-1565

2020

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Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs

Journal of neurochemistry, 2009-05, Vol.109 (s1), p.139-144

2009

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In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1

The Journal of pharmacology and experimental therapeutics, 2015-08, Vol.354 (2), p.166

2015

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Structure activity relationship of selective GABA uptake inhibitors

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2480-2488

2015

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Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

Journal of cerebral blood flow and metabolism, 2018-01, Vol.38 (1), p.166-173

2018

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Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

Neuroscience letters, 2013-06, Vol.546, p.6-10

2013

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Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

Molecular pharmacology, 2016-02, Vol.89 (2), p.253-262

2016

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Discovery of ( R )-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

Frontiers in chemistry, 2022-11, Vol.10, p.1008233-1008233

2022

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Selective mGAT2 (BGT-1) GABA Uptake Inhibitors: Design, Synthesis, and Pharmacological Characterization

Journal of medicinal chemistry, 2013-03, Vol.56 (5), p.2160-2164

2013

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Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors

Molecular pharmacology, 2007-10, Vol.72 (4), p.907-920

2007

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Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro

PloS one, 2013-07, Vol.8 (7), p.e67653

2013

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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

ACS chemical biology, 2014-09, Vol.9 (9), p.2131-2138

2014

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Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

Advances in neurobiology, 2017-01, Vol.16, p.283-296

2017

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Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors

Angewandte Chemie (International ed.), 2011-09, Vol.50 (39), p.9100-9103

2011

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Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3

ACS chemical neuroscience, 2015-09, Vol.6 (9), p.1591-1599

2015

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Transporters As Drug Targets

1, 2017

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Synthesis and Characterisation of Substrate-Based Peptides as Inhibitors of Histone Demethylase KDM4C

Protein and peptide letters, 2016-01, Vol.23 (9), p.772

2016

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Derivatives of (R)‑3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

Journal of medicinal chemistry, 2022-01, Vol.65 (1), p.734-746

2022

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In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

Biological chemistry, 2023-03, Vol.404 (4), p.255

2023

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Identification of AICP as a GluN2C-Selective N -Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

Molecular pharmacology, 2017-08, Vol.92 (2), p.151-161

2017

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Inhibitors of histone demethylases

Bioorganic & medicinal chemistry, 2011-06, Vol.19 (12), p.3625-3636

2011

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Erythrina Alkaloid Analogues as nAChR Antagonists–A Flexible Platform for Leads in Drug Discovery

Journal of organic chemistry, 2021-06, Vol.86 (12), p.8248-8262

2021

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Use of the 4‑Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4467-4482

2019

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GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (31), p.1

2021

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α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs

In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1

Structure activity relationship of selective GABA uptake inhibitors

Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

Discovery of ( R )-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

Selective mGAT2 (BGT-1) GABA Uptake Inhibitors: Design, Synthesis, and Pharmacological Characterization

Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors

Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro

Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors

Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3

Transporters As Drug Targets

Synthesis and Characterisation of Substrate-Based Peptides as Inhibitors of Histone Demethylase KDM4C

Derivatives of (R)‑3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

Identification of AICP as a GluN2C-Selective N -Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

Inhibitors of histone demethylases

Erythrina Alkaloid Analogues as nAChR Antagonists–A Flexible Platform for Leads in Drug Discovery

Use of the 4‑Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

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