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Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.2154-2171

2019

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Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

British journal of pharmacology, 1999-12, Vol.128 (7), p.1393-1398

1999

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Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

Protein science, 2003-02, Vol.12 (2), p.349-360

2003

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Mechanism of Time-Dependent Inhibition of Polypeptide Deformylase by Actinonin

Biochemistry (Easton), 2005-01, Vol.44 (1), p.253-260

2005

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Hexanoate as a starter unit in polyketide biosynthesis

Journal of the American Chemical Society, 1984-06, Vol.106 (13), p.3868-3869

1984

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Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3274-3277

1993

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Methoxymethyl-directed aryl metalation. Total synthesis of (.+-.)-averufin

Journal of the American Chemical Society, 1981-11, Vol.103 (23), p.6885-6888

1981

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Concerning the role of nidurufin in aflatoxin biosynthesis

Journal of the American Chemical Society, 1985-01, Vol.107 (1), p.270-271

1985

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SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions

The Journal of pharmacology and experimental therapeutics, 1998-01, Vol.284 (1), p.420

1998

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1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Journal of medicinal chemistry, 1998-03, Vol.41 (6), p.821-835

1998

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Stable isotope studies of anthraquinone intermediates in the aflatoxin pathway

Tetrahedron, 1983, Vol.39 (21), p.3575-3582

1983

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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [ 3H]rolipram binding

Biochemical pharmacology, 1996-04, Vol.51 (7), p.949-956

1996

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Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig

The Journal of pharmacology and experimental therapeutics, 1998-12, Vol.287 (3), p.988

1998

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Synthesis and absolute configuration of (+)-averufin

Journal of organic chemistry, 1985-12, Vol.50 (25), p.5426-5428

1985

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Bisfuran formation in aflatoxin biosynthesis: the role of versiconal acetate

Journal of the American Chemical Society, 1982-11, Vol.104 (22), p.6154-6155

1982

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Synthesis of averufin and its role in aflatoxin B1 biosynthesis

Journal of the Chemical Society, Perkin Transactions 1, 1988 (4), p.839

1988

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Bisfuran formation in aflatoxin biosynthesis: the fate of the averufin side chain

Journal of the American Chemical Society, 1982-11, Vol.104 (22), p.6152-6153

1982

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The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-cyclopentyloxy)-4-methoxyphenyl-pyrrolidin-2-one

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3274-3277

1993

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New Perspectives on Aflatoxin Biosynthesis

Advances in Applied Microbiology, 1983, Vol.29, p.53-92

1983

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Stereochemical correlation of (-)-averantin

Tetrahedron letters, 1986, Vol.27 (8), p.887-888

1986

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Chapter 19. Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents

Annual Reports in Medicinal Chemistry, 1994, Vol.29, p.185-194

1994

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PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION

The Journal of Antibiotics, 1987/07/25, Vol.40(7), pp.970-990

1987

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13. - Molecular Aspects of Inhibitor Interaction with PDE4

Phosphodiesterase Inhibitors, 1996, p.185,I-207,II

1996

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The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis: Individual Patient Data From Five Randomized Trials

Annals of internal medicine, 2023-09, Vol.176 (9), p.1181-1189

2023

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Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake

Phytotherapy research, 2009-09, Vol.23 (9), p.1316-1325

2009

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Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies

Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

Mechanism of Time-Dependent Inhibition of Polypeptide Deformylase by Actinonin

Hexanoate as a starter unit in polyketide biosynthesis

Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Methoxymethyl-directed aryl metalation. Total synthesis of (.+-.)-averufin

Concerning the role of nidurufin in aflatoxin biosynthesis

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions

1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Stable isotope studies of anthraquinone intermediates in the aflatoxin pathway

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [ 3H]rolipram binding

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig

Synthesis and absolute configuration of (+)-averufin

Bisfuran formation in aflatoxin biosynthesis: the role of versiconal acetate

Synthesis of averufin and its role in aflatoxin B1 biosynthesis

Bisfuran formation in aflatoxin biosynthesis: the fate of the averufin side chain

The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-cyclopentyloxy)-4-methoxyphenyl-pyrrolidin-2-one

New Perspectives on Aflatoxin Biosynthesis

Stereochemical correlation of (-)-averantin

Chapter 19. Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents

PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION

13. - Molecular Aspects of Inhibitor Interaction with PDE4

The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis: Individual Patient Data From Five Randomized Trials

Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake

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