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Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors

The Journal of pharmacology and experimental therapeutics, 2019-11, Vol.371 (2), p.299-308

2019

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Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free–Wilson Analysis for Improved In Vivo Efficacy

ACS medicinal chemistry letters, 2023-11, Vol.14 (11), p.1544-1550

2023

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Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2678-2682

2017

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Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.316-320

2017

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Design, synthesis and SAR of novel glucokinase activators

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.2166-2171

2013

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Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure”

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1341-1341

2017

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A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (2), p.281-284

2003

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(2-Acetoxyphenoxy)ethyl (APOE) as a Phosphate Protecting Group in Solid-Phase Synthesis of Oligonucleotides via the Phosphoramidite Approach

Organic process research & development, 2006-03, Vol.10 (2), p.251-256

2006

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Synthesis of biologically active taxol analogs with modified phenylisoserine side chains

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4230-4237

1992

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Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Organic process research & development, 2000-05, Vol.4 (3), p.199-204

2000

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Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

Nucleosides, nucleotides & nucleic acids, 2003-01, Vol.22 (4), p.461-468

2003

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Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

Organic process research & development, 2003-11, Vol.7 (6), p.917-920

2003

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Samarium Diiodide-Mediated Deoxygenation of Taxol: A One-Step Synthesis of 10-Deacetoxytaxol

Journal of organic chemistry, 1994-07, Vol.59 (14), p.4015-4018

1994

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An efficient semisynthesis of taxol from (3 R,4 S)- N-Benzoyl-3-[( t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III

Bioorganic & medicinal chemistry letters, 1993-11, Vol.3 (11), p.2467-2470

1993

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Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (2), p.335-338

1994

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4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

Tetrahedron letters, 1996-09, Vol.37 (37), p.6643-6646

1996

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Stereoselective synthesis of 9β-hydroxytaxanes via reduction with samarium diiodide

Tetrahedron letters, 1995-03, Vol.36 (11), p.1783-1786

1995

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A Convenient Large Scale Synthesis of 4-Cyano-2-butene-1-ol

Synthetic communications, 1996-05, Vol.26 (9), p.1815-1819

1996

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Novel Biologically Active Taxol Analogues: Baccatin III 13-( N-( p-chlorobenzoyl)-(2′ R,3′ S)-3′-phenylisoserinate) and Baccatin III 13-( N-benzoyl-(2′ R,3′ S)-3′-( p-chlorophenyl)isoserinate)

Bioorganic & medicinal chemistry letters, 1992, Vol.2 (4), p.295-298

1992

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Topliss approach to the synthesis of biologically active substituted N-benzoyl taxol analogues

Bioorganic & medicinal chemistry letters, 1994-08, Vol.4 (15), p.1825-1830

1994

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Stability of Phosphorothioate Oligonucleotides in Aqueous Ammonia in Presence of Stainless Steel

Nucleosides & nucleotides, 1999-01, Vol.18 (1), p.89-93

1999

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Synthesis and biology of substituted 3′-phenyl taxol analogues

Bioorganic & medicinal chemistry letters, 1994-10, Vol.4 (19), p.2331-2336

1994

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Efficiency Of Coupling in the Synthesis of Deoxyribonucleotide Phosphorothioates Via Phosphotriester Approach Utilizing Various Activating Reagents

Nucleosides & nucleotides, 1996-01, Vol.15 (6), p.1149-1155

1996

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Semisynthesis and biological activity of taxol analogues: baccatin III 13-( N-benzoyl-(2′ R,3′ S)-3′-( p-tolyl)isoserinate), baccatin III 13-( N-( p-toluoyl)-2′ R,3′ S)-3′-phenylisoserinate), baccatin III 13-( N-benzoyl-(2′ R,3′ S)-3′-( p-trifluoromethylphenyl)isoserinate), and baccatin III 13-( N-( p-trifluoromethylbenzoyl)-(2′ R,3′ S)-3′-phenylisoserinate

Bioorganic & medicinal chemistry letters, 1992-12, Vol.2 (12), p.1751-1754

1992

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Semisynthesis and biological evaluation of brevifoliol 13-[ N-benzoyl-(-2′ R,3′ S)-3′-phenylisoserinate]

Bioorganic & medicinal chemistry letters, 1993-06, Vol.3 (6), p.1349-1350

1993

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Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors

Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free–Wilson Analysis for Improved In Vivo Efficacy

Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

Design, synthesis and SAR of novel glucokinase activators

Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure”

A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters

(2-Acetoxyphenoxy)ethyl (APOE) as a Phosphate Protecting Group in Solid-Phase Synthesis of Oligonucleotides via the Phosphoramidite Approach

Synthesis of biologically active taxol analogs with modified phenylisoserine side chains

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

Samarium Diiodide-Mediated Deoxygenation of Taxol: A One-Step Synthesis of 10-Deacetoxytaxol

An efficient semisynthesis of taxol from (3 R,4 S)- N-Benzoyl-3-[( t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III

Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

4-Cyano-2-butenyl group: A new type of protecting group in oligonucleotide synthesis via phosphoramidite approach

Stereoselective synthesis of 9β-hydroxytaxanes via reduction with samarium diiodide

A Convenient Large Scale Synthesis of 4-Cyano-2-butene-1-ol

Novel Biologically Active Taxol Analogues: Baccatin III 13-( N-( p-chlorobenzoyl)-(2′ R,3′ S)-3′-phenylisoserinate) and Baccatin III 13-( N-benzoyl-(2′ R,3′ S)-3′-( p-chlorophenyl)isoserinate)

Topliss approach to the synthesis of biologically active substituted N-benzoyl taxol analogues

Stability of Phosphorothioate Oligonucleotides in Aqueous Ammonia in Presence of Stainless Steel

Synthesis and biology of substituted 3′-phenyl taxol analogues

Efficiency Of Coupling in the Synthesis of Deoxyribonucleotide Phosphorothioates Via Phosphotriester Approach Utilizing Various Activating Reagents

Semisynthesis and biological evaluation of brevifoliol 13-[ N-benzoyl-(-2′ R,3′ S)-3′-phenylisoserinate]

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