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Validation of a Standardized Method for Enumerating Circulating Endothelial Cells and Progenitors: Flow Cytometry and Molecular and Ultrastructural Analyses

Clinical cancer research, 2009-01, Vol.15 (1), p.267-273

2009

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Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn's disease: report of the OPERA study

Gut, 2018-10, Vol.67 (10), p.1824

2018

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pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

Journal of translational medicine, 2013-03, Vol.11 (1), p.65-65, Article 65

2013

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Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase

The Journal of biological chemistry, 1998-06, Vol.273 (25), p.15559-15564

1998

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825 Anti-MAdCAM-1 Antibody (PF-00547659) for Active Refractory Crohn's Disease: Results of the OPERA Study

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-162-S-162

2015

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867 Anti-MAdCAM Monoclonal Antibody PF-00547659 Does Not Affect Immune Surveillance in the Central Nervous System of Crohn's Disease Patients Who Are Anti-TNF Inadequate Responders: Results From the Tosca Study

Gastroenterology (New York, N.Y. 1943), 2014-05, Vol.146 (5), p.S-150-S-150

2014

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Isolation and Characterization of PDE8A, a Novel Human cAMP-Specific Phosphodiesterase

Biochemical and biophysical research communications, 1998-05, Vol.246 (3), p.570-577

1998

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SAR of a Series of 5,6-Dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines as Potent Inhibitors of Human Eosinophil Phosphodiesterase

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.344-349

2007

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Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.120-125

1996

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Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues: Implications for a New Active Site Model of PDE4

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.266-270

1998

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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.718-721

2006

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7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase

Journal of medicinal chemistry, 1998-06, Vol.41 (13), p.2268-2277

1998

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Characterization of chemokine CCR3 agonist‐mediated eosinophil recruitment in the Brown‐Norway rat

British journal of pharmacology, 1999-10, Vol.128 (3), p.788-794

1999

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(+)-1-(3S,4R)-[3-(4-Phenylbenzyl)-4- hydroxychroman-7-yl]cyclopentane Carboxylic Acid, a Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis Model

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3197-3199

1994

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Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn’s Disease

Journal of Crohn's and colitis, 2018-01, Vol.12 (1), p.77-86

2018

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Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.624-628

1991

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Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis

Journal of investigative dermatology, 1996-07, Vol.107 (1), p.51-56

1996

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Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor

Canadian journal of physiology and pharmacology, 1997-08, Vol.75 (8), p.1001

1997

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Evidence for a similar receptor site for binding of [3H]leukotriene E4 and [3H]leukotriene D4 to the guinea-pig crude lung membrane

Biochemical and biophysical research communications, 1984-08, Vol.122 (3), p.949-954

1984

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Vascular Relaxation in the Spontaneously Hypertensive Rat

Journal of cardiovascular pharmacology, 1981-09, Vol.3 (5), p.1126-1140

1981

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Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H] leukotriene D4 and [3H] leukotriene C4 binding: demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors

Biochemical and biophysical research communications, 1984-03, Vol.119 (2), p.612-617

1984

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The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy

The Journal of pharmacology and experimental therapeutics, 1997-02, Vol.280 (2), p.621

1997

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Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [ 3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles

Bioorganic & medicinal chemistry letters, 1995-09, Vol.5 (17), p.1965-1968

1995

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The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4

The Journal of pharmacology and experimental therapeutics, 1996-09, Vol.278 (3), p.1349

1996

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Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [ 3H]rolipram binding site

Bioorganic & medicinal chemistry letters, 1995-09, Vol.5 (17), p.1969-1972

1995

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Validation of a Standardized Method for Enumerating Circulating Endothelial Cells and Progenitors: Flow Cytometry and Molecular and Ultrastructural Analyses

Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn's disease: report of the OPERA study

pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase

825 Anti-MAdCAM-1 Antibody (PF-00547659) for Active Refractory Crohn's Disease: Results of the OPERA Study

867 Anti-MAdCAM Monoclonal Antibody PF-00547659 Does Not Affect Immune Surveillance in the Central Nervous System of Crohn's Disease Patients Who Are Anti-TNF Inadequate Responders: Results From the Tosca Study

Isolation and Characterization of PDE8A, a Novel Human cAMP-Specific Phosphodiesterase

SAR of a Series of 5,6-Dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines as Potent Inhibitors of Human Eosinophil Phosphodiesterase

Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues: Implications for a New Active Site Model of PDE4

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase

Characterization of chemokine CCR3 agonist‐mediated eosinophil recruitment in the Brown‐Norway rat

(+)-1-(3S,4R)-[3-(4-Phenylbenzyl)-4- hydroxychroman-7-yl]cyclopentane Carboxylic Acid, a Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis Model

Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn’s Disease

Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase

Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis

Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor

Evidence for a similar receptor site for binding of [3H]leukotriene E4 and [3H]leukotriene D4 to the guinea-pig crude lung membrane

Vascular Relaxation in the Spontaneously Hypertensive Rat

Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H] leukotriene D4 and [3H] leukotriene C4 binding: demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy

Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [ 3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4

Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [ 3H]rolipram binding site

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