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PXR: More Than Just a Master Xenobiotic Receptor

Molecular pharmacology, 2018-02, Vol.93 (2), p.119-127

2018

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Targeting xenobiotic receptors PXR and CAR in human diseases

Drug discovery today, 2015-05, Vol.20 (5), p.618-628

2015

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Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450

International journal of molecular sciences, 2017-11, Vol.18 (11), p.2353

2017

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A current structural perspective on PXR and CAR in drug metabolism

Expert opinion on drug metabolism & toxicology, 2018-06, Vol.14 (6), p.635-647

2018

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The interplay of NR4A receptors and the oncogene–tumor suppressor networks in cancer

Cellular signalling, 2015-02, Vol.27 (2), p.257-266

2015

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Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction

Advances in protein chemistry and structural biology, 2018-01, Vol.110, p.31-63

2018

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BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

Cell, 2016-04, Vol.165 (2), p.421-433

2016

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Role of CAR and PXR in xenobiotic sensing and metabolism

Expert opinion on drug metabolism & toxicology, 2012-07, Vol.8 (7), p.803-817

2012

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PXR variants:the impact on drug metabolism and therapeutic responses

Acta pharmaceutica Sinica. B, 2016-09, Vol.6 (5), p.441-449

2016

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SPA70 is a potent antagonist of human pregnane X receptor

Nature communications, 2017-09, Vol.8 (1), p.741-14, Article 741

2017

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Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery

Current drug metabolism, 2017-01, Vol.18 (12), p.1095

2017

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Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Angewandte Chemie (International ed.), 2021-12, Vol.60 (51), p.26663-26670

International ed. in English, 2021

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Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1733-1761

2021

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Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk

Expert opinion on drug metabolism & toxicology, 2016-09, Vol.12 (9), p.997-1010

2016

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Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor

Biochemical pharmacology, 2013-09, Vol.86 (6), p.824-835

2013

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Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor

Drug discovery today, 2019-03, Vol.24 (3), p.906-915

2019

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Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

Biochemical pharmacology, 2014-11, Vol.92 (2), p.389-402

2014

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Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

Cellular and molecular life sciences : CMLS, 2021-01, Vol.78 (1), p.317-335

2021

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PXR and Metabolism

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.01546

Chen, Taosheng

2021

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Efficient field‐programmable gate array‐based reconfigurable accelerator for deep convolution neural network

Electronics letters, 2021-03, Vol.57 (6), p.238-240

2021

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CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

The Journal of experimental medicine, 2018-04, Vol.215 (4), p.1187-1203

2018

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Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (16), p.5231-5236

2015

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A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKCα activation

Journal of experimental & clinical cancer research, 2024-04, Vol.43 (1), p.97-97

2024

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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

Journal of medicinal chemistry, 2020-02, Vol.63 (3), p.1415-1433

2020

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A phosphotyrosine switch regulates organic cation transporters

Nature communications, 2016-03, Vol.7 (1), p.10880-10880, Article 10880

2016

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PXR: More Than Just a Master Xenobiotic Receptor

Targeting xenobiotic receptors PXR and CAR in human diseases

Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450

A current structural perspective on PXR and CAR in drug metabolism

The interplay of NR4A receptors and the oncogene–tumor suppressor networks in cancer

Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

Role of CAR and PXR in xenobiotic sensing and metabolism

PXR variants:the impact on drug metabolism and therapeutic responses

SPA70 is a potent antagonist of human pregnane X receptor

Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70

Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk

Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor

Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

PXR and Metabolism

Efficient field‐programmable gate array‐based reconfigurable accelerator for deep convolution neural network

CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKCα activation

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

A phosphotyrosine switch regulates organic cation transporters

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