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Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation

Genome Biology, 2023-03, Vol.24 (1), p.41-41, Article 41

2023

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Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Journal of medicinal chemistry, 2016-12, Vol.59 (23), p.10549-10563

2016

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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Accounts of chemical research, 2008-01, Vol.41 (1), p.50-59

2008

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Differential Susceptibility to Axonopathy in Necrotic and Non-Necrotic Perinatal White Matter Injury

Stroke (1970), 2012-01, Vol.43 (1), p.178-184

2012

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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9162-9183

2017

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HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

Journal of thoracic oncology, 2014-03, Vol.9 (3), p.285-294

2014

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An Enantioselective Total Synthesis of (+)-Geissoschizine

Organic letters, 1999-07, Vol.1 (1), p.79-82

1999

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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Cancer research communications, 2023-09, Vol.3 (9), p.1731-1742

2023

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Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3158-3162

2016

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A review of HCV protease inhibitors

Current opinion in investigational drugs (London, England : 2000), 2009-08, Vol.10 (8), p.821

2009

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Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.754-765

2012

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I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5336-5341

2011

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A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2089-2101

2012

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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics

Bioorganic & medicinal chemistry, 2014-01, Vol.22 (1), p.447-458

2014

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Second-Generation Highly Potent and Selective Inhibitors of the Hepatitis C Virus NS3 Serine Protease

Journal of medicinal chemistry, 2009-03, Vol.52 (5), p.1370-1379

2009

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Discovery of an irreversible HCV NS5B polymerase inhibitor

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6585-6587

2013

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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase

Bioorganic & medicinal chemistry, 2013-04, Vol.21 (7), p.2007-2017

2013

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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2617-2621

2010

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II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.713-717

2012

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Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.567-574

2006

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Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P4-Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles

Journal of medicinal chemistry, 2009-06, Vol.52 (12), p.3679-3688

2009

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Toward Second Generation Hepatitis C Virus NS3 Serine Protease Inhibitors: Discovery of Novel P4 Modified Analogues with Improved Potency and Pharmacokinetic Profile

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2806-2817

2009

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Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1105-1109

2009

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Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.995-1005

2006

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Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Differential Susceptibility to Axonopathy in Necrotic and Non-Necrotic Perinatal White Matter Injury

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor

HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

An Enantioselective Total Synthesis of (+)-Geissoschizine

Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity

A review of HCV protease inhibitors

Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors

Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics

Second-Generation Highly Potent and Selective Inhibitors of the Hepatitis C Virus NS3 Serine Protease

Discovery of an irreversible HCV NS5B polymerase inhibitor

Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor

II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides

Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P4-Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles

Toward Second Generation Hepatitis C Virus NS3 Serine Protease Inhibitors: Discovery of Novel P4 Modified Analogues with Improved Potency and Pharmacokinetic Profile

Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings

Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles

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