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MD‐2 as the target of a novel small molecule, L6H21, in the attenuation of LPS‐induced inflammatory response and sepsis

British journal of pharmacology, 2015-09, Vol.172 (17), p.4391-4405

2015

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Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents

European journal of medicinal chemistry, 2014-03, Vol.74, p.671-682

2014

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Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2

The Journal of pharmacology and experimental therapeutics, 2015-06, Vol.353 (3), p.539

2015

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Discovery of a Novel MyD88 Inhibitor M20 and Its Protection Against Sepsis-Mediated Acute Lung Injury

Frontiers in pharmacology, 2021-11, Vol.12, p.775117-775117

2021

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Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2

European journal of medical research, 2024-01, Vol.29 (1), p.65-65, Article 65

2024

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Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

Frontiers in pharmacology, 2023-02, Vol.14, p.1098463-1098463

2023

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Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers

Frontiers in pharmacology, 2020-01, Vol.10, p.1533-1533

2020

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Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways

Biomedicine & pharmacotherapy, 2021-09, Vol.141, p.111874-111874, Article 111874

2021

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α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

Nature (London), 2018-01, Vol.553 (7689), p.461-466

2018

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Structural basis for FGF hormone signalling

Nature (London), 2023-06, Vol.618 (7966), p.862-870

2023

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Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

Cancer letters, 2016-05, Vol.375 (1), p.114-126

2016

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Small molecule inhibition of fibroblast growth factor receptors in cancer

Cytokine & growth factor reviews, 2013-10, Vol.24 (5), p.467-475

2013

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C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23

American journal of physiology. Renal physiology, 2024-04, Vol.326 (4), p.F584

2024

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Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

International immunopharmacology, 2023-07, Vol.120, p.110292-110292, Article 110292

2023

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Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a

Biochimica et biophysica acta. Molecular basis of disease, 2024-06, Vol.1870 (5), p.167140-167140, Article 167140

2024

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A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation

Toxicology and applied pharmacology, 2021-10, Vol.428, p.115648, Article 115648

2021

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Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.6938-6958

2023

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Discovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2436-2451

2016

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Determine the enzymatic kinetic characteristics of CYP3A4 variants utilizing artemether-lumefantrine

Food and chemical toxicology, 2023-11, Vol.181, p.114065-114065, Article 114065

2023

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Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

European journal of medicinal chemistry, 2018-01, Vol.143, p.361-375

2018

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Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents

European journal of medicinal chemistry, 2013-06, Vol.64, p.292-301

2013

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Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity

Journal of cellular and molecular medicine, 2016-08, Vol.20 (8), p.1427-1442

2016

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Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

Scientific reports, 2016-04, Vol.6 (1), p.25130, Article 25130

2016

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Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives

ACS medicinal chemistry letters, 2013-01, Vol.4 (1), p.69-74

2013

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Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury

European journal of medicinal chemistry, 2017-10, Vol.139, p.726-740

2017

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MD‐2 as the target of a novel small molecule, L6H21, in the attenuation of LPS‐induced inflammatory response and sepsis

Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents

Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2

Discovery of a Novel MyD88 Inhibitor M20 and Its Protection Against Sepsis-Mediated Acute Lung Injury

Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2

Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers

Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

Structural basis for FGF hormone signalling

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

Small molecule inhibition of fibroblast growth factor receptors in cancer

C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23

Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a

A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation

Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen

Discovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury

Determine the enzymatic kinetic characteristics of CYP3A4 variants utilizing artemether-lumefantrine

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents

Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity

Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives

Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury

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