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Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

Brain, behavior, and immunity, 2020-03, Vol.85, p.21-28

2020

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Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

Nature communications, 2024-01, Vol.15 (1), p.490-490, Article 490

2024

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Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

Scientific reports, 2015-10, Vol.5 (1), p.15791-15791, Article 15791

2015

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Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans

Journal of lipid research, 2023-09, Vol.64 (9), p.100424-100424, Article 100424

2023

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Oleic acid‐bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation

The FEBS journal, 2023-04, Vol.290 (7), p.1798-1821

2023

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Dyslipidemia in retinal metabolic disorders

EMBO molecular medicine, 2019-10, Vol.11 (10), p.e10473-n/a

2019

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Rapid de‐esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

Journal of neurochemistry, 2011-02, Vol.116 (3), p.363-373

2011

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Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

Journal of lipid research, 2014-01, Vol.55 (1), p.62-74

2014

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The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

Journal of lipid research, 2013-09, Vol.54 (9), p.2410-2422

2013

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Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

Neurochemistry international, 2009-12, Vol.55 (7), p.476-482

2009

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Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations

Frontiers in cell and developmental biology, 2022-09, Vol.10, p.982564

2022

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Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids[S]

Journal of lipid research, 2015-02, Vol.56 (2), p.390-402

2015

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Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study

Nutrients, 2023-02, Vol.15 (5), p.1238

2023

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Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex

PloS one, 2015-07, Vol.10 (7), p.e0132675-e0132675

2015

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The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations

Journal of lipid research, 2008-01, Vol.49 (1), p.147-152

2008

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Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model

Epilepsy & behavior, 2014-04, Vol.33, p.138-143

2014

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β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels

Prostaglandins, leukotrienes and essential fatty acids, 2015-01, Vol.92, p.33-40

2015

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Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption

Pharmacology & therapeutics (Oxford), 2023-08, Vol.248, p.108437-108437, Article 108437

2023

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Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons

Molecular and cellular endocrinology, 2022-11, Vol.557, p.111753-111753, Article 111753

2022

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Brain PUFA Concentrations Are Differentially Affected by Interactions of Diet, Sex, Brain Regions, and Phospholipid Pools in Mice

The Journal of nutrition, 2020-12, Vol.150 (12), p.3123-3132

2020

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Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Science advances, 2020-08, Vol.6 (35), p.eaba7457-eaba7457

2020

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Rapid β-oxidation of eicosapentaenoic acid in mouse brain: An in situ study

Prostaglandins, leukotrienes and essential fatty acids, 2009-02, Vol.80 (2), p.157-163

2009

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Regulation of brain polyunsaturated fatty acid uptake and turnover

Prostaglandins, leukotrienes and essential fatty acids, 2008-09, Vol.79 (3), p.85-91

2008

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Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress

Journal of neurochemistry, 2021-11, Vol.159 (4), p.742-761

2021

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The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats

The Journal of nutritional biochemistry, 2016-04, Vol.30, p.167-176

2016

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Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans

Oleic acid‐bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation

Dyslipidemia in retinal metabolic disorders

Rapid de‐esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations

Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids[S]

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex

The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations

Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model

β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels

Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption

Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons

Brain PUFA Concentrations Are Differentially Affected by Interactions of Diet, Sex, Brain Regions, and Phospholipid Pools in Mice

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Rapid β-oxidation of eicosapentaenoic acid in mouse brain: An in situ study

Regulation of brain polyunsaturated fatty acid uptake and turnover

Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress

The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats

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