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Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

The Journal of pharmacology and experimental therapeutics, 2015-09, Vol.354 (3), p.471

2015

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Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain

The Journal of neuroscience, 2005-03, Vol.25 (12), p.3126-3131

2005

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Neuronal Hyperpolarization-Activated Pacemaker Channels Drive Neuropathic Pain

The Journal of neuroscience, 2003-02, Vol.23 (4), p.1169-1178

2003

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Sodium Channel Blockers for the Treatment of Neuropathic Pain

Neurotherapeutics, 2009-10, Vol.6 (4), p.663-678

2009

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Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

Journal of headache and pain, 2015-06, Vol.16 (1), p.57-57, Article 57

2015

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Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1857-1872

2005

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Activation of TRPA1 by Farnesyl Thiosalicylic Acid

Molecular pharmacology, 2008-04, Vol.73 (4), p.1225-1234

2008

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Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs

The Journal of pharmacology and experimental therapeutics, 2007-11, Vol.323 (2), p.665

2007

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The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial

Neuropsychopharmacology (New York, N.Y.), 2021-04, Vol.46 (5), p.1011-1019

2021

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Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

Anesthesia and analgesia, 2009, Vol.108 (1), p.316-329

2009

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Hyperpolarization-Activated, Cation-Nonselective, Cyclic Nucleotide-Modulated Channel Blockade Alleviates Mechanical Allodynia and Suppresses Ectopic Discharge in Spinal Nerve Ligated Rats

The journal of pain, 2005-07, Vol.6 (7), p.417-424

2005

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Effects of the selective orexin-2 receptor antagonist JNJ-48816274 on sleep initiated in the circadian wake maintenance zone: a randomised trial

Neuropsychopharmacology (New York, N.Y.), 2022-02, Vol.47 (3), p.719-727

2022

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

European journal of pharmacology, 2011-08, Vol.663 (1), p.40-50

2011

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Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse

European journal of pharmacology, 2020-08, Vol.880, p.173171, Article 173171

2020

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Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine

Pain (Amsterdam), 1996-12, Vol.68 (2), p.293-299

1996

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Spinal pharmacology of tactile allodynia in diabetic rats

British journal of pharmacology, 1997-12, Vol.122 (7), p.1478-1482

1997

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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

British journal of pharmacology, 2006-05, Vol.148 (1), p.102-113

2006

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Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

ACS medicinal chemistry letters, 2015-12, Vol.6 (12), p.1204-1208

2015

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A Phase 1 First‐in‐Human Pharmacokinetic and Pharmacodynamic Study of JNJ‐64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase

Clinical pharmacology in drug development, 2023-06, Vol.12 (6), p.611-624

2023

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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4781-4784

2016

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Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat

The Journal of pharmacology and experimental therapeutics, 1997-02, Vol.280 (2), p.829

1997

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Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.737-741

2014

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The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3109-3114

2016

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1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1280-1284

2014

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Discovery of a novel series of selective HCN1 blockers

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5197-5201

2011

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Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain

Neuronal Hyperpolarization-Activated Pacemaker Channels Drive Neuropathic Pain

Sodium Channel Blockers for the Treatment of Neuropathic Pain

Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist

Activation of TRPA1 by Farnesyl Thiosalicylic Acid

Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs

The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial

Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

Hyperpolarization-Activated, Cation-Nonselective, Cyclic Nucleotide-Modulated Channel Blockade Alleviates Mechanical Allodynia and Suppresses Ectopic Discharge in Spinal Nerve Ligated Rats

Effects of the selective orexin-2 receptor antagonist JNJ-48816274 on sleep initiated in the circadian wake maintenance zone: a randomised trial

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse

Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine

Spinal pharmacology of tactile allodynia in diabetic rats

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

A Phase 1 First‐in‐Human Pharmacokinetic and Pharmacodynamic Study of JNJ‐64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase

The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists

Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat

Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

Discovery of a novel series of selective HCN1 blockers

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