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Alzheimer's Disease and Its Possible Evolutionary Origin: Hypothesis

Cells (Basel, Switzerland), 2023-06, Vol.12 (12), p.1618

2023

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NMR analysis of the correlation of metabolic changes in blood and cerebrospinal fluid in Alzheimer model male and female mice

PloS one, 2021-05, Vol.16 (5), p.e0250568-e0250568

2021

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Reduction of the immunostainable length of the hippocampal dentate granule cells’ primary cilia in 3xAD-transgenic mice producing human Aβ1-42 and tau

Biochemical and biophysical research communications, 2012-10, Vol.427 (1), p.218-222

2012

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The neuronal primary cilium: Driver of neurogenesis and memory formation in the hippocampal dentate gyrus?

Cellular signalling, 2009-09, Vol.21 (9), p.1351-1355

2009

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Preventing the spread of Alzheimer's disease neuropathology: a role for calcilytics?

Current pharmaceutical biotechnology, 2015-01, Vol.16 (8), p.696-706

2015

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Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation

Brain research, 2006-11, Vol.1119 (1), p.40-49

2006

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Calpain‐mediated truncation of dihydropyrimidinase‐like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity

Journal of neurochemistry, 2005-10, Vol.95 (2), p.466-474

2005

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Calcium-sensing receptor (CaSR) in human brain's pathophysiology: roles in late-onset Alzheimer's disease (LOAD)

Current pharmaceutical biotechnology, 2009-04, Vol.10 (3), p.317-326

2009

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Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons

Biochemical and biophysical research communications, 2007-11, Vol.363 (1), p.190-193

2007

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PLA2 signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase-like 3 protein in response to NMDA excitotoxicity

Neuroscience letters, 2008-01, Vol.430 (3), p.197-202

2008

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The Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's Neuropathology

Cells (Basel, Switzerland), 2015-07, Vol.4 (3), p.253-274

2015

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Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog

Pharmaceutical research, 2022-07, Vol.39 (7), p.1497-1507

2022

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Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach

Biochemical and biophysical research communications, 2006-04, Vol.342 (3), p.791-799

2006

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P1‐345: The shortening of somatostatin receptor‐3‐bearing primary cilia of neurons in the dentate gyri of Aβ1‐42 and P301L‐tau accumulating transgenic Alzheimer‐mice but not in mice accumulating only Aβ1‐42

Alzheimer's & dementia, 2010-07, Vol.6, p.S273-S273

Chakravarthy, Balu

2010

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The shortening of somatostatin receptor-3-bearing primary cilia of neurons in the dentate gyri of Aβ1-42 and P301L-tau accumulating transgenic Alzheimer-mice but not in mice accumulating only Aβ1-42

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S273-S273

Chakravarthy, Balu

2010

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P1‐345: The shortening of somatostatin receptor‐3‐bearing primary cilia of neurons in the dentate gyri of Aβ 1‐42 and P301L‐tau accumulating transgenic Alzheimer‐mice but not in mice accumulating only Aβ 1‐42

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_9)

Chakravarthy, Balu

2010

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Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

The Neuroscientist (Baltimore, Md.), 2015-02, Vol.21 (1), p.9-29

2015

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Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Biochimica et biophysica acta, 2013-10, Vol.1832 (10), p.1634-1652

2013

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Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients

Neurochemistry international, 2016-12, Vol.101, p.22-29

2016

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The gas7 protein potentiates NGF-mediated differentiation of PC12 cells

Brain research, 2005-03, Vol.1036 (1), p.27-34

2005

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Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic

Journal of cerebral blood flow and metabolism, 2022-05, Vol.42 (5), p.788-801

2022

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Alzheimer's disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

International journal of molecular medicine, 2013-01, Vol.31 (1), p.3-10

2013

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Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart

Brain research, 1999-05, Vol.827 (1), p.143-151

1999

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Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice

Journal of Alzheimer's disease, 2010, Vol.19 (3), p.915

2010

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A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM‐1) protein binds β‐amyloid (Aβ1‐42) oligomers

Journal of neurochemistry, 2013-08, Vol.126 (3), p.415-424

2013

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Alzheimer's Disease and Its Possible Evolutionary Origin: Hypothesis

NMR analysis of the correlation of metabolic changes in blood and cerebrospinal fluid in Alzheimer model male and female mice

Reduction of the immunostainable length of the hippocampal dentate granule cells’ primary cilia in 3xAD-transgenic mice producing human Aβ1-42 and tau

The neuronal primary cilium: Driver of neurogenesis and memory formation in the hippocampal dentate gyrus?

Preventing the spread of Alzheimer's disease neuropathology: a role for calcilytics?

Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation

Calpain‐mediated truncation of dihydropyrimidinase‐like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity

Calcium-sensing receptor (CaSR) in human brain's pathophysiology: roles in late-onset Alzheimer's disease (LOAD)

Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons

PLA2 signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase-like 3 protein in response to NMDA excitotoxicity

The Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's Neuropathology

Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog

Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach

P1‐345: The shortening of somatostatin receptor‐3‐bearing primary cilia of neurons in the dentate gyri of Aβ1‐42 and P301L‐tau accumulating transgenic Alzheimer‐mice but not in mice accumulating only Aβ1‐42

The shortening of somatostatin receptor-3-bearing primary cilia of neurons in the dentate gyri of Aβ1-42 and P301L-tau accumulating transgenic Alzheimer-mice but not in mice accumulating only Aβ1-42

P1‐345: The shortening of somatostatin receptor‐3‐bearing primary cilia of neurons in the dentate gyri of Aβ 1‐42 and P301L‐tau accumulating transgenic Alzheimer‐mice but not in mice accumulating only Aβ 1‐42

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients

The gas7 protein potentiates NGF-mediated differentiation of PC12 cells

Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic

Alzheimer's disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart

Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice

A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM‐1) protein binds β‐amyloid (Aβ1‐42) oligomers

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